(1R,2S)-2-[(difluoroacetyl)amino]-3-fluoro-1-{4-[6-(3-hydroxyoxetan-3-yl)pyridin-3-yl]phenyl}propyl dihydrogen phosphate

Base Information

Chemical Name:(1R,2S)-2-[(difluoroacetyl)amino]-3-fluoro-1-{4-[6-(3-hydroxyoxetan-3-yl)pyridin-3-yl]phenyl}propyl dihydrogen phosphate
CAS No.:1582262-11-0
Molecular Formula:C₁₉H₂₀F₃N₂O₇P
Molecular Weight:476.346
Hs Code.:

Synonyms:(1R,2S)-2-[(difluoroacetyl)amino]-3-fluoro-1-{4-[6-(3-hydroxyoxetan-3-yl)pyridin-3-yl]phenyl}propyl dihydrogen phosphate

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Chemical Property of (1R,2S)-2-[(difluoroacetyl)amino]-3-fluoro-1-{4-[6-(3-hydroxyoxetan-3-yl)pyridin-3-yl]phenyl}propyl dihydrogen phosphate

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Technology Process of (1R,2S)-2-[(difluoroacetyl)amino]-3-fluoro-1-{4-[6-(3-hydroxyoxetan-3-yl)pyridin-3-yl]phenyl}propyl dihydrogen phosphate

There total 9 articles about (1R,2S)-2-[(difluoroacetyl)amino]-3-fluoro-1-{4-[6-(3-hydroxyoxetan-3-yl)pyridin-3-yl]phenyl}propyl dihydrogen phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1582263-11-3
dibenzyl (1R,2S)-2-[(difluoroacetyl)amino]-3-fluoro-1-{4-[6-(3-hydroxyoxetan-3-yl)pyridin-3-yl]phenyl}propyl phosphate

: 1582262-11-0
(1R,2S)-2-[(difluoroacetyl)amino]-3-fluoro-1-{4-[6-(3-hydroxyoxetan-3-yl)pyridin-3-yl]phenyl}propyl dihydrogen phosphate

Guidance literature:: With 5%-palladium/activated carbon; hydrogen; In ethanol; water; at 20 ℃; for 1h; under 760.051 Torr;

Reference yield:

: 1582261-94-6
2,2-difluoro-N-((1R,2S)-3-fluoro-1-hydroxy-1-(4-(6-(3-hydroxyoxetan-3-yl)pyridin-3-yl)phenyl)propan-2-yl)acetamide

: 1582262-11-0
(1R,2S)-2-[(difluoroacetyl)amino]-3-fluoro-1-{4-[6-(3-hydroxyoxetan-3-yl)pyridin-3-yl]phenyl}propyl dihydrogen phosphate

Guidance literature:: Multi-step reaction with 2 steps

1.1: pyridine; trifluoroacetic acid / tetrahydrofuran / 0.08 h / 0 °C

1.2: 0 - 20 °C

1.3: 0 - 20 °C

2.1: hydrogen; 5%-palladium/activated carbon / water; ethanol / 1 h / 20 °C / 760.05 Torr

With pyridine; 5%-palladium/activated carbon; hydrogen; trifluoroacetic acid; In tetrahydrofuran; ethanol; water;

Reference yield:

: 1207758-80-2
3-(5-bromopyridin-2-yl)oxetan-3-ol

: 1582262-11-0
(1R,2S)-2-[(difluoroacetyl)amino]-3-fluoro-1-{4-[6-(3-hydroxyoxetan-3-yl)pyridin-3-yl]phenyl}propyl dihydrogen phosphate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium carbonate; palladium bis[bis(diphenylphosphino)ferrocene] dichloride / 1,4-dioxane; water / 2 h / 60 °C / Inert atmosphere

2.1: trifluoroacetic acid; water / dichloromethane / 0 - 20 °C

3.1: pyridine; trifluoroacetic acid / tetrahydrofuran / 0.08 h / 0 °C

3.2: 0 - 20 °C

3.3: 0 - 20 °C

4.1: hydrogen; 5%-palladium/activated carbon / water; ethanol / 1 h / 20 °C / 760.05 Torr

With pyridine; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; 5%-palladium/activated carbon; water; hydrogen; sodium carbonate; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water;