2,2-difluoro-N-((1R,2S)-3-fluoro-1-hydroxy-1-(4-(6-(3-hydroxyoxetan-3-yl)pyridin-3-yl)phenyl)propan-2-yl)acetamide

Base Information

Chemical Name:2,2-difluoro-N-((1R,2S)-3-fluoro-1-hydroxy-1-(4-(6-(3-hydroxyoxetan-3-yl)pyridin-3-yl)phenyl)propan-2-yl)acetamide
CAS No.:1582261-94-6
Molecular Formula:C₁₉H₁₉F₃N₂O₄
Molecular Weight:396.366
Hs Code.:

Synonyms:2,2-difluoro-N-((1R,2S)-3-fluoro-1-hydroxy-1-(4-(6-(3-hydroxyoxetan-3-yl)pyridin-3-yl)phenyl)propan-2-yl)acetamide

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Chemical Property of 2,2-difluoro-N-((1R,2S)-3-fluoro-1-hydroxy-1-(4-(6-(3-hydroxyoxetan-3-yl)pyridin-3-yl)phenyl)propan-2-yl)acetamide

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Technology Process of 2,2-difluoro-N-((1R,2S)-3-fluoro-1-hydroxy-1-(4-(6-(3-hydroxyoxetan-3-yl)pyridin-3-yl)phenyl)propan-2-yl)acetamide

There total 7 articles about 2,2-difluoro-N-((1R,2S)-3-fluoro-1-hydroxy-1-(4-(6-(3-hydroxyoxetan-3-yl)pyridin-3-yl)phenyl)propan-2-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1582262-85-8
3-(5-{4-[(4S,5R)-3-(difluoroacetyl)-4-(fluoromethyl)-2,2-dimethyl-1,3-oxazolidin-5-yl]phenyl}pyridin-2-yl)oxetan-3-ol

: 1582261-94-6
2,2-difluoro-N-((1R,2S)-3-fluoro-1-hydroxy-1-(4-(6-(3-hydroxyoxetan-3-yl)pyridin-3-yl)phenyl)propan-2-yl)acetamide

Guidance literature:: With water; trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃;

Reference yield:

: 927689-70-1
(1R,2S)-2-amino-3-fluoro-1-(4-iodophenyl)propan-1-ol

: 1582261-94-6
2,2-difluoro-N-((1R,2S)-3-fluoro-1-hydroxy-1-(4-(6-(3-hydroxyoxetan-3-yl)pyridin-3-yl)phenyl)propan-2-yl)acetamide

Guidance literature:: Multi-step reaction with 5 steps

1: 20 °C

2: triethylamine / dichloromethane / 0 - 20 °C

3: potassium acetate; bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane / 22 h / 90 °C / Inert atmosphere

4: sodium carbonate; palladium bis[bis(diphenylphosphino)ferrocene] dichloride / 1,4-dioxane; water / 2 h / 60 °C / Inert atmosphere

5: trifluoroacetic acid; water / dichloromethane / 0 - 20 °C

With bis-triphenylphosphine-palladium(II) chloride; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; water; potassium acetate; sodium carbonate; triethylamine; trifluoroacetic acid; In 1,4-dioxane; dichloromethane; water;

Reference yield:

: 624-28-2
2,5-dibromopyridine

: 1582261-94-6
2,2-difluoro-N-((1R,2S)-3-fluoro-1-hydroxy-1-(4-(6-(3-hydroxyoxetan-3-yl)pyridin-3-yl)phenyl)propan-2-yl)acetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium / toluene; hexane / 0.67 h / -78 °C / Inert atmosphere

1.2: 0.5 h / -78 °C

2.1: sodium carbonate; palladium bis[bis(diphenylphosphino)ferrocene] dichloride / 1,4-dioxane; water / 2 h / 60 °C / Inert atmosphere

3.1: trifluoroacetic acid; water / dichloromethane / 0 - 20 °C

With n-butyllithium; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; water; sodium carbonate; trifluoroacetic acid; In 1,4-dioxane; hexane; dichloromethane; water; toluene;