dibenzyl (1R,2S)-2-[(difluoroacetyl)amino]-3-fluoro-1-{4-[6-(3-hydroxyoxetan-3-yl)pyridin-3-yl]phenyl}propyl phosphate

Base Information

Chemical Name:dibenzyl (1R,2S)-2-[(difluoroacetyl)amino]-3-fluoro-1-{4-[6-(3-hydroxyoxetan-3-yl)pyridin-3-yl]phenyl}propyl phosphate
CAS No.:1582263-11-3
Molecular Formula:C₃₃H₃₂F₃N₂O₇P
Molecular Weight:656.595
Hs Code.:

Synonyms:dibenzyl (1R,2S)-2-[(difluoroacetyl)amino]-3-fluoro-1-{4-[6-(3-hydroxyoxetan-3-yl)pyridin-3-yl]phenyl}propyl phosphate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of dibenzyl (1R,2S)-2-[(difluoroacetyl)amino]-3-fluoro-1-{4-[6-(3-hydroxyoxetan-3-yl)pyridin-3-yl]phenyl}propyl phosphate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of dibenzyl (1R,2S)-2-[(difluoroacetyl)amino]-3-fluoro-1-{4-[6-(3-hydroxyoxetan-3-yl)pyridin-3-yl]phenyl}propyl phosphate

There total 8 articles about dibenzyl (1R,2S)-2-[(difluoroacetyl)amino]-3-fluoro-1-{4-[6-(3-hydroxyoxetan-3-yl)pyridin-3-yl]phenyl}propyl phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1582261-94-6
2,2-difluoro-N-((1R,2S)-3-fluoro-1-hydroxy-1-(4-(6-(3-hydroxyoxetan-3-yl)pyridin-3-yl)phenyl)propan-2-yl)acetamide

: 7722-84-1
dihydrogen peroxide

: 108549-23-1
Dibenzyl N,N-diisopropylphosphoramidite

: 1582263-11-3
dibenzyl (1R,2S)-2-[(difluoroacetyl)amino]-3-fluoro-1-{4-[6-(3-hydroxyoxetan-3-yl)pyridin-3-yl]phenyl}propyl phosphate

Guidance literature:: 2,2-difluoro-N-((1R,2S)-3-fluoro-1-hydroxy-1-(4-(6-(3-hydroxyoxetan-3-yl)pyridin-3-yl)phenyl)propan-2-yl)acetamide; With pyridine; trifluoroacetic acid; In tetrahydrofuran; at 0 ℃; for 0.0833333h;

Dibenzyl N,N-diisopropylphosphoramidite; In tetrahydrofuran; at 0 - 20 ℃;

dihydrogen peroxide; In tetrahydrofuran; water; at 0 - 20 ℃;

Reference yield:

: 1207758-80-2
3-(5-bromopyridin-2-yl)oxetan-3-ol

: 1582263-11-3
dibenzyl (1R,2S)-2-[(difluoroacetyl)amino]-3-fluoro-1-{4-[6-(3-hydroxyoxetan-3-yl)pyridin-3-yl]phenyl}propyl phosphate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium carbonate; palladium bis[bis(diphenylphosphino)ferrocene] dichloride / 1,4-dioxane; water / 2 h / 60 °C / Inert atmosphere

2.1: trifluoroacetic acid; water / dichloromethane / 0 - 20 °C

3.1: pyridine; trifluoroacetic acid / tetrahydrofuran / 0.08 h / 0 °C

3.2: 0 - 20 °C

3.3: 0 - 20 °C

With pyridine; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; water; sodium carbonate; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water;

Reference yield:

: 1431551-88-0
(4S,5R)-4-(fluoromethyl)-5-(4-iodophenyl)-2,2-dimethyloxazolidine

: 1582263-11-3
dibenzyl (1R,2S)-2-[(difluoroacetyl)amino]-3-fluoro-1-{4-[6-(3-hydroxyoxetan-3-yl)pyridin-3-yl]phenyl}propyl phosphate

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / dichloromethane / 0 - 20 °C

2.1: potassium acetate; bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane / 22 h / 90 °C / Inert atmosphere

3.1: sodium carbonate; palladium bis[bis(diphenylphosphino)ferrocene] dichloride / 1,4-dioxane; water / 2 h / 60 °C / Inert atmosphere

4.1: trifluoroacetic acid; water / dichloromethane / 0 - 20 °C

5.1: pyridine; trifluoroacetic acid / tetrahydrofuran / 0.08 h / 0 °C

5.2: 0 - 20 °C

5.3: 0 - 20 °C

With pyridine; bis-triphenylphosphine-palladium(II) chloride; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; water; potassium acetate; sodium carbonate; triethylamine; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water;