(5E,7E)-2-(tert-butyldiphenylsilyloxy)-10-(4-methoxybenzyloxy)-7-methyldeca-5,7-dienoic acid methoxy(methyl)amide

Base Information

Chemical Name:(5E,7E)-2-(tert-butyldiphenylsilyloxy)-10-(4-methoxybenzyloxy)-7-methyldeca-5,7-dienoic acid methoxy(methyl)amide
CAS No.:851009-45-5
Molecular Formula:C₃₇H₄₉NO₅Si
Molecular Weight:615.885
Hs Code.:

Synonyms:(5E,7E)-2-(tert-butyldiphenylsilyloxy)-10-(4-methoxybenzyloxy)-7-methyldeca-5,7-dienoic acid methoxy(methyl)amide

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Chemical Property of (5E,7E)-2-(tert-butyldiphenylsilyloxy)-10-(4-methoxybenzyloxy)-7-methyldeca-5,7-dienoic acid methoxy(methyl)amide

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Technology Process of (5E,7E)-2-(tert-butyldiphenylsilyloxy)-10-(4-methoxybenzyloxy)-7-methyldeca-5,7-dienoic acid methoxy(methyl)amide

There total 5 articles about (5E,7E)-2-(tert-butyldiphenylsilyloxy)-10-(4-methoxybenzyloxy)-7-methyldeca-5,7-dienoic acid methoxy(methyl)amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 851009-44-4
(5E,7E)-2-(tert-Butyl-diphenyl-silanyloxy)-10-(4-methoxy-benzyloxy)-7-methyl-deca-5,7-dienoic acid methyl ester

: 6638-79-5
N,O-dimethylhydroxylamine*hydrochloride

: 851009-45-5
(5E,7E)-2-(tert-butyldiphenylsilyloxy)-10-(4-methoxybenzyloxy)-7-methyldeca-5,7-dienoic acid methoxy(methyl)amide

Guidance literature:: With isopropylmagnesium chloride; In tetrahydrofuran; diethyl ether; at -20 ℃; for 1h;
DOI:10.1021/ol050191g

Reference yield:

: (E)-(6-methoxy-6-oxohex-1-en-1-yl)boronic acid

: 851009-45-5
(5E,7E)-2-(tert-butyldiphenylsilyloxy)-10-(4-methoxybenzyloxy)-7-methyldeca-5,7-dienoic acid methoxy(methyl)amide

Guidance literature:: Multi-step reaction with 4 steps

1.1: 64 percent / Tl₂CO₃ / Pd(PPh₃)4 / tetrahydrofuran; H₂O / 0.5 h / 23 °C

2.1: KHMDS / tetrahydrofuran / 0.5 h / -78 °C

2.2: 73 percent / rac-trans-2-(phenylsulfonyl)-3-phenyloxaziridine / tetrahydrofuran / 1 h

3.1: DMAP; imidazole / dimethylformamide

4.1: 83 percent / i-PrMgCl / tetrahydrofuran; diethyl ether / 1 h / -20 °C

With 1H-imidazole; dmap; Ti₂CO₃; isopropylmagnesium chloride; potassium hexamethylsilazane; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; diethyl ether; water; N,N-dimethyl-formamide; 1.1: Suzuki coupling reaction;
DOI:10.1021/ol050191g

Reference yield:

: 500702-36-3
(2E)-2-iodo-5-[(4-methoxybenzyl)oxy]pent-2-ene

: 851009-45-5
(5E,7E)-2-(tert-butyldiphenylsilyloxy)-10-(4-methoxybenzyloxy)-7-methyldeca-5,7-dienoic acid methoxy(methyl)amide

Guidance literature:: Multi-step reaction with 4 steps

1.1: 64 percent / Tl₂CO₃ / Pd(PPh₃)4 / tetrahydrofuran; H₂O / 0.5 h / 23 °C

2.1: KHMDS / tetrahydrofuran / 0.5 h / -78 °C

2.2: 73 percent / rac-trans-2-(phenylsulfonyl)-3-phenyloxaziridine / tetrahydrofuran / 1 h

3.1: DMAP; imidazole / dimethylformamide

4.1: 83 percent / i-PrMgCl / tetrahydrofuran; diethyl ether / 1 h / -20 °C

With 1H-imidazole; dmap; Ti₂CO₃; isopropylmagnesium chloride; potassium hexamethylsilazane; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; diethyl ether; water; N,N-dimethyl-formamide; 1.1: Suzuki coupling reaction;
DOI:10.1021/ol050191g