2-(2-(hydroxymethyl)-3-(1-methyl-6-oxo-5-(pyrimidin-4-ylamino)-1,6-dihydropyridin-3-yl)phenyl)-3,4,6,7,8,9-hexahydropyrido[3,4-b]imidazo[4,5-c]pyridine-1-one

Base Information

Chemical Name:2-(2-(hydroxymethyl)-3-(1-methyl-6-oxo-5-(pyrimidin-4-ylamino)-1,6-dihydropyridin-3-yl)phenyl)-3,4,6,7,8,9-hexahydropyrido[3,4-b]imidazo[4,5-c]pyridine-1-one
CAS No.:1346670-08-3
Molecular Formula:C₂₇H₂₇N₇O₃
Molecular Weight:497.556
Hs Code.:

2-(2-(hydroxymethyl)-3-(1-methyl-6-oxo-5-(pyrimidin-4-ylamino)-1,6-dihydropyridin-3-yl)phenyl)-3,4,6,7,8,9-hexahydropyrido[3,4-b]imidazo[4,5-c]pyridine-1-one

Synonyms:2-(2-(hydroxymethyl)-3-(1-methyl-6-oxo-5-(pyrimidin-4-ylamino)-1,6-dihydropyridin-3-yl)phenyl)-3,4,6,7,8,9-hexahydropyrido[3,4-b]imidazo[4,5-c]pyridine-1-one

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Chemical Property of 2-(2-(hydroxymethyl)-3-(1-methyl-6-oxo-5-(pyrimidin-4-ylamino)-1,6-dihydropyridin-3-yl)phenyl)-3,4,6,7,8,9-hexahydropyrido[3,4-b]imidazo[4,5-c]pyridine-1-one

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Technology Process of 2-(2-(hydroxymethyl)-3-(1-methyl-6-oxo-5-(pyrimidin-4-ylamino)-1,6-dihydropyridin-3-yl)phenyl)-3,4,6,7,8,9-hexahydropyrido[3,4-b]imidazo[4,5-c]pyridine-1-one

There total 12 articles about 2-(2-(hydroxymethyl)-3-(1-methyl-6-oxo-5-(pyrimidin-4-ylamino)-1,6-dihydropyridin-3-yl)phenyl)-3,4,6,7,8,9-hexahydropyrido[3,4-b]imidazo[4,5-c]pyridine-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₉H₂₉N₇O₄

: 1346670-08-3
2-(2-(hydroxymethyl)-3-(1-methyl-6-oxo-5-(pyrimidin-4-ylamino)-1,6-dihydropyridin-3-yl)phenyl)-3,4,6,7,8,9-hexahydropyrido[3,4-b]imidazo[4,5-c]pyridine-1-one

Guidance literature:: C₂₉H₂₉N₇O₄; With potassium carbonate; In methanol; at 20 ℃; for 2h;

With water; In methanol;

Reference yield:

: 69321-60-4
2,6-dibromotoluene

: 1346670-08-3
2-(2-(hydroxymethyl)-3-(1-methyl-6-oxo-5-(pyrimidin-4-ylamino)-1,6-dihydropyridin-3-yl)phenyl)-3,4,6,7,8,9-hexahydropyrido[3,4-b]imidazo[4,5-c]pyridine-1-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-Bromosuccinimide / 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 14 h / 80 °C / Inert atmosphere

2.1: N,N-dimethyl-formamide / 14 h / 20 °C / Inert atmosphere

3.1: caesium carbonate / copper(l) iodide / 1-methyl-pyrrolidin-2-one / 16 h / 120 °C / Inert atmosphere

3.2: 2 h / 20 °C

4.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 5 h / 100 °C / Inert atmosphere

5.1: potassium carbonate / methanol / 2 h / 20 °C

With N-Bromosuccinimide; sodium carbonate; potassium carbonate; caesium carbonate; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 2,2'-azobis(isobutyronitrile); In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; methanol; tetrachloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 13091-23-1
4-chloro-3-nitropyridine

: 1346670-08-3
2-(2-(hydroxymethyl)-3-(1-methyl-6-oxo-5-(pyrimidin-4-ylamino)-1,6-dihydropyridin-3-yl)phenyl)-3,4,6,7,8,9-hexahydropyrido[3,4-b]imidazo[4,5-c]pyridine-1-one

Guidance literature:: Multi-step reaction with 8 steps

1.1: ethanol / 2 h / 70 °C / Inert atmosphere

2.1: triethyl phosphite / 24 h / 110 °C / Inert atmosphere

3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1.5 h / 0 - 20 °C

4.1: acetic anhydride / 1.5 h / 140 °C / Inert atmosphere

5.1: hydrogen; acetic acid / palladium 10% on activated carbon / 48 h / 85 °C / 18100.7 Torr

5.2: pH 9

6.1: caesium carbonate / copper(l) iodide / 1-methyl-pyrrolidin-2-one / 16 h / 120 °C / Inert atmosphere

6.2: 2 h / 20 °C

7.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 5 h / 100 °C / Inert atmosphere

8.1: potassium carbonate / methanol / 2 h / 20 °C

With hydrogen; acetic anhydride; sodium carbonate; potassium carbonate; caesium carbonate; acetic acid; 3-chloro-benzenecarboperoxoic acid; triethyl phosphite; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; methanol; ethanol; dichloromethane; water;