1-benzyl-4-butyl-4-methylpyrazolidine-3,5-dione

Base Information

• Chemical Name: 1-benzyl-4-butyl-4-methylpyrazolidine-3,5-dione
• CAS No.: 291773-90-5
• Molecular Formula: C₁₅H₂₀N₂O₂
• Molecular Weight: 260.336
• Mol file: 291773-90-5.mol

Synonyms:1-benzyl-4-butyl-4-methylpyrazolidine-3,5-dione

Chemical Property of 1-benzyl-4-butyl-4-methylpyrazolidine-3,5-dione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-benzyl-4-butyl-4-methylpyrazolidine-3,5-dione

There total 3 articles about 1-benzyl-4-butyl-4-methylpyrazolidine-3,5-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

butylmethylpropanedioic acid diethyl ester (55114-29-9) + Benzylhydrazine (555-96-4) → 1-benzyl-4-butyl-4-methylpyrazolidine-3,5-dione (291773-90-5)

Guidance literature:

Benzylhydrazine; With ethanol; sodium; at 20 ℃; for 1h;

butylmethylpropanedioic acid diethyl ester; In chlorobenzene; for 12h; Heating;

DOI:10.1021/jm9904147

Reference yield: 35.0%

benzylhydrazine dihydrochloride (20570-96-1) + butylmethylpropanedioic acid diethyl ester (55114-29-9) → 1-benzyl-4-butyl-4-methylpyrazolidine-3,5-dione (291773-90-5)

Guidance literature:

benzylhydrazine dihydrochloride; With sodium ethanolate; In ethanol; at 20 ℃; for 1h;

butylmethylpropanedioic acid diethyl ester; In chlorobenzene; for 12h; Heating;

DOI:10.1002/jhet.5570370530

Reference yield:

diethyl butylmalonate (133-08-4) → 1-benzyl-4-butyl-4-methylpyrazolidine-3,5-dione (291773-90-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: Na; EtOH

1.2: 59 percent / tetrahydrofuran / 2 h / 20 °C

2.1: Na; EtOH / 1 h / 20 °C

2.2: 35 percent / chlorobenzene / 12 h / Heating

With ethanol; sodium; 1.1: Metallation / 1.2: Methylation / 2.1: Metallation / 2.2: Cycloaddition;

DOI:10.1021/jm9904147

upstream raw materials:

butylmethylpropanedioic acid diethyl ester

Benzylhydrazine

benzylhydrazine dihydrochloride

diethyl butylmalonate

Downstream raw materials:

1,4-dibutyl-2-[[2'-(N-tert-butylaminosulfonyl)(1,1'-biphenyl)-4-yl]methyl]-4-methylpyrazolidine-3,5-dione

4'-(2,4-dibutyl-4-methyl-3,5-dioxo-pyrazolidin-1-ylmethyl)-biphenyl-2-sulfonic acid amide

1,4-dibutyl-4-methylpyrazolidine-3,5-dione

Refernces

• 1、 Le Bourdonnec,Meulon,Yous,Houssin,Henichart. "A new synthesis of N-alkyl pyrazolidine-3,5-diones and tetrahydropyridazine-3,6-diones". . p. 1209 - 1212. Retrieved 2007/10/03.