N₁-[1-(4-bromophenyl)-2-(1-pyrrolidinyl)ethyl]-N₂-(3,4-dichlorophenyl)-N₁,N₂-dimethylglycinamide

Base Information

• Chemical Name: N₁-[1-(4-bromophenyl)-2-(1-pyrrolidinyl)ethyl]-N₂-(3,4-dichlorophenyl)-N₁,N₂-dimethylglycinamide
• CAS No.: 1003873-11-7
• Molecular Formula: C₂₂H₂₆BrCl₂N₃O
• Molecular Weight: 499.278

Synonyms:N₁-[1-(4-bromophenyl)-2-(1-pyrrolidinyl)ethyl]-N₂-(3,4-dichlorophenyl)-N₁,N₂-dimethylglycinamide

Chemical Property of N₁-[1-(4-bromophenyl)-2-(1-pyrrolidinyl)ethyl]-N₂-(3,4-dichlorophenyl)-N₁,N₂-dimethylglycinamide

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Technology Process of N₁-[1-(4-bromophenyl)-2-(1-pyrrolidinyl)ethyl]-N₂-(3,4-dichlorophenyl)-N₁,N₂-dimethylglycinamide

There total 1 articles about N₁-[1-(4-bromophenyl)-2-(1-pyrrolidinyl)ethyl]-N₂-(3,4-dichlorophenyl)-N₁,N₂-dimethylglycinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

N-(3,4-dichlorophenyl)-N-methylglycine (1003878-30-5) + N-methyl-1-(4-bromophenyl)-2-(pyrrolidin-1-yl)ethane-1-amine (1003873-10-6) → N1-[1-(4-bromophenyl)-2-(1-pyrrolidinyl)ethyl]-N2-(3,4-dichlorophenyl)-N1,N2-dimethylglycinamide (1003873-11-7)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 20 ℃; for 18h;

Reference yield: 47.0%

N1-[1-(4-bromophenyl)-2-(1-pyrrolidinyl)ethyl]-N2-(3,4-dichlorophenyl)-N1,N2-dimethylglycinamide (1003873-11-7) + 4-Chlorophenylboronic acid (1679-18-1) → N1-[1-(4'-chloro-4-biphenylyl)-2-(1-pyrrolidinyl)ethyl]-N2-(3,4-dichlorophenyl)-N1,N2-dimethylglycinamide (1003873-12-8)

Guidance literature:

With sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; water; at 185 ℃; for 0.1h; sealed glass reaction tube; microwave irradiation;

Reference yield: 47.0%

N1-[1-(4-bromophenyl)-2-(1-pyrrolidinyl)ethyl]-N2-(3,4-dichlorophenyl)-N1,N2-dimethylglycinamide (1003873-11-7) + 2-(aminocarbonyl)benzeneboronic acid → 4'-[1-[[N-(3,4-dichlorophenyl)-N-methylglycyl](methyl)amino]-2-(1-pyrrolidinyl)ethyl]-2-biphenylcarboxamide (1003873-85-5)

Guidance literature:

With sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In water; N,N-dimethyl-formamide; at 80 ℃; for 18h;

upstream raw materials:

N-(3,4-dichlorophenyl)-N-methylglycine

N-methyl-1-(4-bromophenyl)-2-(pyrrolidin-1-yl)ethane-1-amine

Downstream raw materials:

N₁-[1-(4'-chloro-4-biphenylyl)-2-(1-pyrrolidinyl)ethyl]-N₂-(3,4-dichlorophenyl)-N₁,N₂-dimethylglycinamide

4'-[1-[[N-(3,4-dichlorophenyl)-N-methylglycyl](methyl)amino]-2-(1-pyrrolidinyl)ethyl]-2-biphenylcarboxamide

N₁-[1-(4-biphenylyl)-2-(1-pyrrolidinyl)ethyl]-N₂-(3,4-dichlorophenyl)-N₁,N₂-dimethylglycinamide

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