4-((S)-2-amino-1-phenyl-ethylamino)-quinazoline-8-carboxylic acid amide

Base Information

Chemical Name:4-((S)-2-amino-1-phenyl-ethylamino)-quinazoline-8-carboxylic acid amide
CAS No.:1240472-90-5
Molecular Formula:C₁₇H₁₇N₅O
Molecular Weight:307.355
Hs Code.:

Synonyms:4-((S)-2-amino-1-phenyl-ethylamino)-quinazoline-8-carboxylic acid amide

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Chemical Property of 4-((S)-2-amino-1-phenyl-ethylamino)-quinazoline-8-carboxylic acid amide

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Technology Process of 4-((S)-2-amino-1-phenyl-ethylamino)-quinazoline-8-carboxylic acid amide

There total 7 articles about 4-((S)-2-amino-1-phenyl-ethylamino)-quinazoline-8-carboxylic acid amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 1240472-84-7
4-((S)-2-azido-1-phenyl-ethylamino)-quinazoline-8-carboxylic acid amide

: 1240472-90-5
4-((S)-2-amino-1-phenyl-ethylamino)-quinazoline-8-carboxylic acid amide

Guidance literature:: With hydrogen; 5%-palladium/activated carbon; In ethanol; chloroform; for 48h;

Reference yield:

: 39622-79-2
2-aminoisophthalic acid

: 1240472-90-5
4-((S)-2-amino-1-phenyl-ethylamino)-quinazoline-8-carboxylic acid amide

Guidance literature:: Multi-step reaction with 6 steps

1: 160 °C / Inert atmosphere

2: sulfuric acid / 84 h / 75 °C

3: N-ethyl-N,N-diisopropylamine; trichlorophosphate; N-benzyl-N,N,N-triethylammonium chloride / acetonitrile / 0.5 h / 90 °C

4: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 3 h / 50 °C / Inert atmosphere

5: ammonium hydroxide / tetrahydrofuran; isopropyl alcohol / 24 h

6: 5%-palladium/activated carbon; hydrogen / ethanol; chloroform / 48 h

With ammonium hydroxide; sulfuric acid; 5%-palladium/activated carbon; N-benzyl-N,N,N-triethylammonium chloride; hydrogen; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In tetrahydrofuran; ethanol; chloroform; isopropyl alcohol; acetonitrile;
DOI:10.1021/acs.jmedchem.1c01087

Reference yield:

: 903130-01-8
4-chloro-quinazoline-8-carboxylic acid methyl ester

: 1240472-90-5
4-((S)-2-amino-1-phenyl-ethylamino)-quinazoline-8-carboxylic acid amide

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 3 h / 50 °C / Inert atmosphere

2: ammonium hydroxide / tetrahydrofuran; isopropyl alcohol / 24 h

3: hydrogen / 5%-palladium/activated carbon / ethanol; chloroform / 48 h

With ammonium hydroxide; hydrogen; N-ethyl-N,N-diisopropylamine; 5%-palladium/activated carbon; In tetrahydrofuran; ethanol; chloroform; isopropyl alcohol;