(R)-N-(4-(4-(3-(3-tert-butyl-1-(4-hydroxyphenyl)-1H-pyrazol-5-yl)ureido)-2,3-dichloro phenoxy)pyridin-2-yl)-3-(dimethylamino)pyrrolidine-1-carboxamide

Base Information

Chemical Name:(R)-N-(4-(4-(3-(3-tert-butyl-1-(4-hydroxyphenyl)-1H-pyrazol-5-yl)ureido)-2,3-dichloro phenoxy)pyridin-2-yl)-3-(dimethylamino)pyrrolidine-1-carboxamide
CAS No.:1337930-74-1
Molecular Formula:C₃₂H₃₆Cl₂N₈O₄
Molecular Weight:667.595
Hs Code.:

Synonyms:(R)-N-(4-(4-(3-(3-tert-butyl-1-(4-hydroxyphenyl)-1H-pyrazol-5-yl)ureido)-2,3-dichloro phenoxy)pyridin-2-yl)-3-(dimethylamino)pyrrolidine-1-carboxamide

Suppliers and Price of (R)-N-(4-(4-(3-(3-tert-butyl-1-(4-hydroxyphenyl)-1H-pyrazol-5-yl)ureido)-2,3-dichloro phenoxy)pyridin-2-yl)-3-(dimethylamino)pyrrolidine-1-carboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (R)-N-(4-(4-(3-(3-tert-butyl-1-(4-hydroxyphenyl)-1H-pyrazol-5-yl)ureido)-2,3-dichloro phenoxy)pyridin-2-yl)-3-(dimethylamino)pyrrolidine-1-carboxamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (R)-N-(4-(4-(3-(3-tert-butyl-1-(4-hydroxyphenyl)-1H-pyrazol-5-yl)ureido)-2,3-dichloro phenoxy)pyridin-2-yl)-3-(dimethylamino)pyrrolidine-1-carboxamide

There total 6 articles about (R)-N-(4-(4-(3-(3-tert-butyl-1-(4-hydroxyphenyl)-1H-pyrazol-5-yl)ureido)-2,3-dichloro phenoxy)pyridin-2-yl)-3-(dimethylamino)pyrrolidine-1-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 1337932-28-1
(R)-N-(4-(4-(3-(3-tert-butyl-1-(4-(tert-butyldimethylsilyloxy)phenyl)-1H-pyrazol-5-yl)ureido)-2,3-dichlorophenoxy)pyridin-2-yl)-3-(dimethylamino)pyrrolidine-1-carboxamide

: 1337930-74-1
(R)-N-(4-(4-(3-(3-tert-butyl-1-(4-hydroxyphenyl)-1H-pyrazol-5-yl)ureido)-2,3-dichloro phenoxy)pyridin-2-yl)-3-(dimethylamino)pyrrolidine-1-carboxamide

Guidance literature:: (R)-N-(4-(4-(3-(3-tert-butyl-1-(4-(tert-butyldimethylsilyloxy)phenyl)-1H-pyrazol-5-yl)ureido)-2,3-dichlorophenoxy)pyridin-2-yl)-3-(dimethylamino)pyrrolidine-1-carboxamide; With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 0.166667h;

With sodium hydrogencarbonate; In tetrahydrofuran; water; ethyl acetate;

Reference yield:

: 33631-05-9
2-amino-4-hydroxypyridine

: 1337930-74-1
(R)-N-(4-(4-(3-(3-tert-butyl-1-(4-hydroxyphenyl)-1H-pyrazol-5-yl)ureido)-2,3-dichloro phenoxy)pyridin-2-yl)-3-(dimethylamino)pyrrolidine-1-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 0.5 h / 20 °C

1.2: 16 h / 20 °C

2.1: triethylamine / dichloromethane / 0.17 h / 0 °C

2.2: 1.5 h / 0 - 20 °C

3.1: hydrogen; acetic acid / palladium 10% on activated carbon / dichloromethane; methanol / 40 °C / Thales H-cube

4.1: dichloromethane / 3.5 h / 20 °C

4.2: 16 h / 20 °C

5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.17 h / 20 °C

With tetrabutyl ammonium fluoride; hydrogen; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane; acetonitrile;

Reference yield:

: 1337931-94-8
4-(2,3-dichloro-4-nitrophenoxy)pyridin-2-amine

: 1337930-74-1
(R)-N-(4-(4-(3-(3-tert-butyl-1-(4-hydroxyphenyl)-1H-pyrazol-5-yl)ureido)-2,3-dichloro phenoxy)pyridin-2-yl)-3-(dimethylamino)pyrrolidine-1-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / dichloromethane / 0.17 h / 0 °C

1.2: 1.5 h / 0 - 20 °C

2.1: hydrogen; acetic acid / palladium 10% on activated carbon / dichloromethane; methanol / 40 °C / Thales H-cube

3.1: dichloromethane / 3.5 h / 20 °C

3.2: 16 h / 20 °C

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.17 h / 20 °C

With tetrabutyl ammonium fluoride; hydrogen; acetic acid; triethylamine; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane;