(R)-N-(4-(4-(3-(3-tert-butyl-1-(4-(tert-butyldimethylsilyloxy)phenyl)-1H-pyrazol-5-yl)ureido)-2,3-dichlorophenoxy)pyridin-2-yl)-3-(dimethylamino)pyrrolidine-1-carboxamide

Base Information

Chemical Name:(R)-N-(4-(4-(3-(3-tert-butyl-1-(4-(tert-butyldimethylsilyloxy)phenyl)-1H-pyrazol-5-yl)ureido)-2,3-dichlorophenoxy)pyridin-2-yl)-3-(dimethylamino)pyrrolidine-1-carboxamide
CAS No.:1337932-28-1
Molecular Formula:C₃₈H₅₀Cl₂N₈O₄Si
Molecular Weight:781.858
Hs Code.:

(R)-N-(4-(4-(3-(3-tert-butyl-1-(4-(tert-butyldimethylsilyloxy)phenyl)-1H-pyrazol-5-yl)ureido)-2,3-dichlorophenoxy)pyridin-2-yl)-3-(dimethylamino)pyrrolidine-1-carboxamide

Synonyms:(R)-N-(4-(4-(3-(3-tert-butyl-1-(4-(tert-butyldimethylsilyloxy)phenyl)-1H-pyrazol-5-yl)ureido)-2,3-dichlorophenoxy)pyridin-2-yl)-3-(dimethylamino)pyrrolidine-1-carboxamide

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Chemical Property of (R)-N-(4-(4-(3-(3-tert-butyl-1-(4-(tert-butyldimethylsilyloxy)phenyl)-1H-pyrazol-5-yl)ureido)-2,3-dichlorophenoxy)pyridin-2-yl)-3-(dimethylamino)pyrrolidine-1-carboxamide

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Technology Process of (R)-N-(4-(4-(3-(3-tert-butyl-1-(4-(tert-butyldimethylsilyloxy)phenyl)-1H-pyrazol-5-yl)ureido)-2,3-dichlorophenoxy)pyridin-2-yl)-3-(dimethylamino)pyrrolidine-1-carboxamide

There total 5 articles about (R)-N-(4-(4-(3-(3-tert-butyl-1-(4-(tert-butyldimethylsilyloxy)phenyl)-1H-pyrazol-5-yl)ureido)-2,3-dichlorophenoxy)pyridin-2-yl)-3-(dimethylamino)pyrrolidine-1-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 876301-36-9
3-tert-butyl-1-(4-(tert-butyldimethyl-silyloxy)phenyl)-1H-pyrazol-5-amine

: 1337932-00-9
(R)-N-(4-(4-amino-2,3-dichlorophenoxy)pyridin-2-yl)-3-(dimethyl amino)pyrrolidine-1-carboxamide

: 530-62-1
1,1'-carbonyldiimidazole

: 1337932-28-1
(R)-N-(4-(4-(3-(3-tert-butyl-1-(4-(tert-butyldimethylsilyloxy)phenyl)-1H-pyrazol-5-yl)ureido)-2,3-dichlorophenoxy)pyridin-2-yl)-3-(dimethylamino)pyrrolidine-1-carboxamide

Guidance literature:: 3-tert-butyl-1-(4-(tert-butyldimethyl-silyloxy)phenyl)-1H-pyrazol-5-amine; 1,1'-carbonyldiimidazole; In dichloromethane; at 20 ℃; for 3.5h;

(R)-N-(4-(4-amino-2,3-dichlorophenoxy)pyridin-2-yl)-3-(dimethyl amino)pyrrolidine-1-carboxamide; In dichloromethane; at 20 ℃; for 16h;

Reference yield:

: 33631-05-9
2-amino-4-hydroxypyridine

: 1337932-28-1
(R)-N-(4-(4-(3-(3-tert-butyl-1-(4-(tert-butyldimethylsilyloxy)phenyl)-1H-pyrazol-5-yl)ureido)-2,3-dichlorophenoxy)pyridin-2-yl)-3-(dimethylamino)pyrrolidine-1-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 0.5 h / 20 °C

1.2: 16 h / 20 °C

2.1: triethylamine / dichloromethane / 0.17 h / 0 °C

2.2: 1.5 h / 0 - 20 °C

3.1: hydrogen; acetic acid / palladium 10% on activated carbon / dichloromethane; methanol / 40 °C / Thales H-cube

4.1: dichloromethane / 3.5 h / 20 °C

4.2: 16 h / 20 °C

With hydrogen; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; palladium 10% on activated carbon; In methanol; dichloromethane; acetonitrile;

Reference yield:

: 1337931-94-8
4-(2,3-dichloro-4-nitrophenoxy)pyridin-2-amine

: 1337932-28-1
(R)-N-(4-(4-(3-(3-tert-butyl-1-(4-(tert-butyldimethylsilyloxy)phenyl)-1H-pyrazol-5-yl)ureido)-2,3-dichlorophenoxy)pyridin-2-yl)-3-(dimethylamino)pyrrolidine-1-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / dichloromethane / 0.17 h / 0 °C

1.2: 1.5 h / 0 - 20 °C

2.1: hydrogen; acetic acid / palladium 10% on activated carbon / dichloromethane; methanol / 40 °C / Thales H-cube

3.1: dichloromethane / 3.5 h / 20 °C

3.2: 16 h / 20 °C

With hydrogen; acetic acid; triethylamine; palladium 10% on activated carbon; In methanol; dichloromethane;