Technology Process of N1,N6,N13-tris(2-nitrobenzenesulfonyl)-1,13-diamino-6-azatridecane
There total 8 articles about N1,N6,N13-tris(2-nitrobenzenesulfonyl)-1,13-diamino-6-azatridecane which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
N6-(2-nitrobenzenesulfonyl)-1,13-diamino-6-azatridecane dihydrochloride;
With
potassium carbonate;
In
N,N-dimethyl-formamide; acetonitrile;
at 20 ℃;
for 1h;
2-Nitrobenzenesulfonyl chloride;
In
acetonitrile;
at 0 - 20 ℃;
DOI:10.1016/S0040-4020(98)00441-4
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 95 percent / Et3N / tetrahydrofuran / 0 - 20 °C
2.1: 70 percent / diethyl azodicarboxylate; Ph3P / tetrahydrofuran / 2 h / 20 °C
3.1: 90 percent / CF3COOH / CH2Cl2 / 5 h / 20 °C
4.1: K2CO3 / dimethylformamide; acetonitrile / 1 h / 20 °C
4.2: 77 percent / acetonitrile / 0 - 20 °C
With
potassium carbonate; triethylamine; triphenylphosphine; trifluoroacetic acid; diethylazodicarboxylate;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
1.1: Acylation / 2.1: Condensation / 3.1: Hydrolysis / 4.1: Hydrolysis / 4.2: Acylation;
DOI:10.1016/S0040-4020(98)00441-4
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 68 percent / Et3N / CH2Cl2 / 3 h / 0 - 20 °C
2.1: 93 percent / Et3N / tetrahydrofuran / 0 - 20 °C
3.1: 70 percent / diethyl azodicarboxylate; Ph3P / tetrahydrofuran / 2 h / 20 °C
4.1: 90 percent / CF3COOH / CH2Cl2 / 5 h / 20 °C
5.1: K2CO3 / dimethylformamide; acetonitrile / 1 h / 20 °C
5.2: 77 percent / acetonitrile / 0 - 20 °C
With
potassium carbonate; triethylamine; triphenylphosphine; trifluoroacetic acid; diethylazodicarboxylate;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
1.1: Acylation / 2.1: Acylation / 3.1: Condensation / 4.1: Hydrolysis / 5.1: Hydrolysis / 5.2: Acylation;
DOI:10.1016/S0040-4020(98)00441-4
