3-(3-chloro-4-isopropoxyphenyl)-5-(4-(chloromethyl)phenyl)-1,2,4-oxadiazole

Base Information

Chemical Name:3-(3-chloro-4-isopropoxyphenyl)-5-(4-(chloromethyl)phenyl)-1,2,4-oxadiazole
CAS No.:1311267-00-1
Molecular Formula:C₁₈H₁₆Cl₂N₂O₂
Molecular Weight:363.243
Hs Code.:

Synonyms:3-(3-chloro-4-isopropoxyphenyl)-5-(4-(chloromethyl)phenyl)-1,2,4-oxadiazole

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Chemical Property of 3-(3-chloro-4-isopropoxyphenyl)-5-(4-(chloromethyl)phenyl)-1,2,4-oxadiazole

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Technology Process of 3-(3-chloro-4-isopropoxyphenyl)-5-(4-(chloromethyl)phenyl)-1,2,4-oxadiazole

There total 1 articles about 3-(3-chloro-4-isopropoxyphenyl)-5-(4-(chloromethyl)phenyl)-1,2,4-oxadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1311267-00-1
3-(3-chloro-4-isopropoxyphenyl)-5-(4-(chloromethyl)phenyl)-1,2,4-oxadiazole

Guidance literature:

Reference yield: 63.7%

: 1311267-00-1
3-(3-chloro-4-isopropoxyphenyl)-5-(4-(chloromethyl)phenyl)-1,2,4-oxadiazole

: 603-35-0
triphenylphosphine

: 1311267-07-8
(4-(3-(3-chloro-4-isopropoxyphenyl)-1,2,4-oxadiazol-5-yl)benzyl)triphenylphosphonium chloride

Guidance literature:: In xylene; at 140 ℃; for 18h;

Reference yield:

: 1311267-00-1
3-(3-chloro-4-isopropoxyphenyl)-5-(4-(chloromethyl)phenyl)-1,2,4-oxadiazole

: 1311229-10-3
ethyl 3-(4-(3-(3-chloro-4-isopropoxyphenyl)-1,2,4-oxadiazol-5-yl)benzyl)cyclobutanecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: xylene / 18 h / 140 °C

2.1: sodium hydride / dimethyl sulfoxide / 0.5 h / 0 - 20 °C / Inert atmosphere

2.2: 64.08 h / 20 - 80 °C / Inert atmosphere

3.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 1 h / 20 °C

With hydrogen; sodium hydride; palladium 10% on activated carbon; In dimethyl sulfoxide; ethyl acetate; xylene;