3-(4-(3-(3-chloro-4-isopropoxyphenyl)-1,2,4-oxadiazol-5-yl)benzyl)cyclobutanecarboxylic acid

Base Information

Chemical Name:3-(4-(3-(3-chloro-4-isopropoxyphenyl)-1,2,4-oxadiazol-5-yl)benzyl)cyclobutanecarboxylic acid
CAS No.:1311231-88-5
Molecular Formula:C₂₃H₂₃ClN₂O₄
Molecular Weight:426.9
Hs Code.:

Synonyms:3-(4-(3-(3-chloro-4-isopropoxyphenyl)-1,2,4-oxadiazol-5-yl)benzyl)cyclobutanecarboxylic acid

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Chemical Property of 3-(4-(3-(3-chloro-4-isopropoxyphenyl)-1,2,4-oxadiazol-5-yl)benzyl)cyclobutanecarboxylic acid

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Technology Process of 3-(4-(3-(3-chloro-4-isopropoxyphenyl)-1,2,4-oxadiazol-5-yl)benzyl)cyclobutanecarboxylic acid

There total 5 articles about 3-(4-(3-(3-chloro-4-isopropoxyphenyl)-1,2,4-oxadiazol-5-yl)benzyl)cyclobutanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 1311229-10-3
ethyl 3-(4-(3-(3-chloro-4-isopropoxyphenyl)-1,2,4-oxadiazol-5-yl)benzyl)cyclobutanecarboxylate

: 1311231-88-5
3-(4-(3-(3-chloro-4-isopropoxyphenyl)-1,2,4-oxadiazol-5-yl)benzyl)cyclobutanecarboxylic acid

Guidance literature:: With water; potassium hydroxide; In ethanol; at 100 ℃; for 16h;

Reference yield:

: 87121-89-9
ethyl 3-oxocyclobutanecarboxylate

: 1311231-88-5
3-(4-(3-(3-chloro-4-isopropoxyphenyl)-1,2,4-oxadiazol-5-yl)benzyl)cyclobutanecarboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / dimethyl sulfoxide / 0.5 h / 0 - 20 °C / Inert atmosphere

1.2: 64.08 h / 20 - 80 °C / Inert atmosphere

2.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 1 h / 20 °C

3.1: potassium hydroxide; water / ethanol / 16 h / 100 °C

With water; hydrogen; sodium hydride; potassium hydroxide; palladium 10% on activated carbon; In ethanol; dimethyl sulfoxide; ethyl acetate;

Reference yield:

: 1311267-07-8
(4-(3-(3-chloro-4-isopropoxyphenyl)-1,2,4-oxadiazol-5-yl)benzyl)triphenylphosphonium chloride

: 1311231-88-5
3-(4-(3-(3-chloro-4-isopropoxyphenyl)-1,2,4-oxadiazol-5-yl)benzyl)cyclobutanecarboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / dimethyl sulfoxide / 0.5 h / 0 - 20 °C / Inert atmosphere

1.2: 64.08 h / 20 - 80 °C / Inert atmosphere

2.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 1 h / 20 °C

3.1: potassium hydroxide; water / ethanol / 16 h / 100 °C

With water; hydrogen; sodium hydride; potassium hydroxide; palladium 10% on activated carbon; In ethanol; dimethyl sulfoxide; ethyl acetate;