tert-butyl 1-[3-(2S)-(2-{[4-((E)-2-cyanovinyl)phenyl]-2-cyclopentylacetyl}amino)-4-fluorobenzyl]cyclopropanecarboxylate

Base Information

Chemical Name:tert-butyl 1-[3-(2S)-(2-{[4-((E)-2-cyanovinyl)phenyl]-2-cyclopentylacetyl}amino)-4-fluorobenzyl]cyclopropanecarboxylate
CAS No.:1380606-49-4
Molecular Formula:C₃₁H₃₅FN₂O₃
Molecular Weight:502.629
Hs Code.:

Synonyms:tert-butyl 1-[3-(2S)-(2-{[4-((E)-2-cyanovinyl)phenyl]-2-cyclopentylacetyl}amino)-4-fluorobenzyl]cyclopropanecarboxylate

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Chemical Property of tert-butyl 1-[3-(2S)-(2-{[4-((E)-2-cyanovinyl)phenyl]-2-cyclopentylacetyl}amino)-4-fluorobenzyl]cyclopropanecarboxylate

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Technology Process of tert-butyl 1-[3-(2S)-(2-{[4-((E)-2-cyanovinyl)phenyl]-2-cyclopentylacetyl}amino)-4-fluorobenzyl]cyclopropanecarboxylate

There total 8 articles about tert-butyl 1-[3-(2S)-(2-{[4-((E)-2-cyanovinyl)phenyl]-2-cyclopentylacetyl}amino)-4-fluorobenzyl]cyclopropanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1380605-62-8
(+/-)-tert-butyl 1-(3-{[2-(4-bromophenyl)-2-cyclopentylacetyl]amino}-4-fluorobenzyl)cyclopropanecarboxylate

: 107-13-1,25014-41-9
acrylonitrile

: tert-butyl 1-[3-(2R)-(2-{[4-(2-cyanovinyl)phenyl]-2-cyclopentylacetyl}amino)-4-fluorobenzyl]cyclopropanecarboxylate

: 1380606-49-4
tert-butyl 1-[3-(2S)-(2-{[4-((E)-2-cyanovinyl)phenyl]-2-cyclopentylacetyl}amino)-4-fluorobenzyl]cyclopropanecarboxylate

Guidance literature:: With triethylamine; palladium diacetate; tris-(o-tolyl)phosphine; In N,N-dimethyl-formamide; at 150 ℃; for 2h; Microwave irradiation;

Reference yield:

: 14062-25-0
Ethyl 4-bromophenylacetate

: tert-butyl 1-[3-(2R)-(2-{[4-(2-cyanovinyl)phenyl]-2-cyclopentylacetyl}amino)-4-fluorobenzyl]cyclopropanecarboxylate

: 1380606-49-4
tert-butyl 1-[3-(2S)-(2-{[4-((E)-2-cyanovinyl)phenyl]-2-cyclopentylacetyl}amino)-4-fluorobenzyl]cyclopropanecarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium tert-butylate / N,N-dimethyl-formamide / 0.5 h / 0 °C / Inert atmosphere

1.2: 1 h / 0 - 5 °C

2.1: sodium hydroxide; water / methanol / 3 h / Reflux

2.2: pH 1 - 2

3.1: HATU / N,N-dimethyl-formamide / 0 - 60 °C

4.1: triethylamine / palladium diacetate; tris-(o-tolyl)phosphine / N,N-dimethyl-formamide / 2 h / 150 °C / Microwave irradiation

With potassium tert-butylate; water; triethylamine; HATU; sodium hydroxide; palladium diacetate; tris-(o-tolyl)phosphine; In methanol; N,N-dimethyl-formamide;

Reference yield:

: 1192040-06-4
tert-butyl 1-[3-(benzylamino)-4-fluorobenzyl]cyclopropanecarboxylate

: tert-butyl 1-[3-(2R)-(2-{[4-(2-cyanovinyl)phenyl]-2-cyclopentylacetyl}amino)-4-fluorobenzyl]cyclopropanecarboxylate

: 1380606-49-4
tert-butyl 1-[3-(2S)-(2-{[4-((E)-2-cyanovinyl)phenyl]-2-cyclopentylacetyl}amino)-4-fluorobenzyl]cyclopropanecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen / 20% palladium hydroxide-activated charcoal / ethanol / 18 h / 20 °C / 760.05 Torr

2: HATU / N,N-dimethyl-formamide / 0 - 60 °C

3: triethylamine / palladium diacetate; tris-(o-tolyl)phosphine / N,N-dimethyl-formamide / 2 h / 150 °C / Microwave irradiation

With hydrogen; triethylamine; HATU; 20% palladium hydroxide-activated charcoal; palladium diacetate; tris-(o-tolyl)phosphine; In ethanol; N,N-dimethyl-formamide;