(+/-)-tert-butyl 1-(3-{[2-(4-bromophenyl)-2-cyclopentylacetyl]amino}-4-fluorobenzyl)cyclopropanecarboxylate

Base Information

Chemical Name:(+/-)-tert-butyl 1-(3-{[2-(4-bromophenyl)-2-cyclopentylacetyl]amino}-4-fluorobenzyl)cyclopropanecarboxylate
CAS No.:1380605-62-8
Molecular Formula:C₂₈H₃₃BrFNO₃
Molecular Weight:530.477
Hs Code.:

Synonyms:(+/-)-tert-butyl 1-(3-{[2-(4-bromophenyl)-2-cyclopentylacetyl]amino}-4-fluorobenzyl)cyclopropanecarboxylate

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Chemical Property of (+/-)-tert-butyl 1-(3-{[2-(4-bromophenyl)-2-cyclopentylacetyl]amino}-4-fluorobenzyl)cyclopropanecarboxylate

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Technology Process of (+/-)-tert-butyl 1-(3-{[2-(4-bromophenyl)-2-cyclopentylacetyl]amino}-4-fluorobenzyl)cyclopropanecarboxylate

There total 7 articles about (+/-)-tert-butyl 1-(3-{[2-(4-bromophenyl)-2-cyclopentylacetyl]amino}-4-fluorobenzyl)cyclopropanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1192040-12-2
tert-butyl 1-(3-amino-4-fluorobenzyl)cyclopropanecarboxylate

: 1082453-57-3
(R/S)-(4-bromophenyl)(cyclopentyl)acetic acid

: 1380605-62-8
(+/-)-tert-butyl 1-(3-{[2-(4-bromophenyl)-2-cyclopentylacetyl]amino}-4-fluorobenzyl)cyclopropanecarboxylate

Guidance literature:: With HATU; In N,N-dimethyl-formamide; at 0 - 60 ℃;

Reference yield:

: 87661-20-9
tert-butyl cyclopropanecarboxylate

: 1380605-62-8
(+/-)-tert-butyl 1-(3-{[2-(4-bromophenyl)-2-cyclopentylacetyl]amino}-4-fluorobenzyl)cyclopropanecarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 4 h / -70 - -60 °C / Inert atmosphere

1.2: -60 - 20 °C

2.1: sodium t-butanolate / 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 2 h / 110 °C / Inert atmosphere

3.1: hydrogen / 20% palladium hydroxide-activated charcoal / ethanol / 18 h / 20 °C / 760.05 Torr

4.1: HATU / N,N-dimethyl-formamide / 0 - 60 °C

With n-butyllithium; hydrogen; diisopropylamine; HATU; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 20% palladium hydroxide-activated charcoal; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In tetrahydrofuran; ethanol; hexane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1192040-00-8
tert-butyl 1-(3-bromo-4-fluorobenzyl)cyclopropanecarboxylate

: 1380605-62-8
(+/-)-tert-butyl 1-(3-{[2-(4-bromophenyl)-2-cyclopentylacetyl]amino}-4-fluorobenzyl)cyclopropanecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium t-butanolate / 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 2 h / 110 °C / Inert atmosphere

2: hydrogen / 20% palladium hydroxide-activated charcoal / ethanol / 18 h / 20 °C / 760.05 Torr

3: HATU / N,N-dimethyl-formamide / 0 - 60 °C

With hydrogen; HATU; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 20% palladium hydroxide-activated charcoal; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In ethanol; N,N-dimethyl-formamide; toluene;