6-Chloro-2-(chloromethyl)imidazo[1,2-b]pyridazine

Base Information

• Chemical Name: 6-Chloro-2-(chloromethyl)imidazo[1,2-b]pyridazine
• CAS No.: 154578-23-1
• Molecular Formula: C7H5 Cl2 N3
• Molecular Weight: 202.0407
• Hs Code.: 2933990090
• European Community (EC) Number: 802-707-7
• DSSTox Substance ID: DTXSID90450070
• Nikkaji Number: J2.643.492K
• Wikidata: Q72517731
• Mol file: 154578-23-1.mol

Synonyms:6-chloro-2-(chloromethyl)imidazo[1,2-b]pyridazine;154578-23-1;6-Chloro-2-chloromethylimidazo[1,2-b]pyridazine;SCHEMBL297697;Imidazo[1,2-b]pyridazine, 6-chloro-2-(chloromethyl)-;AMY1710;DTXSID90450070;YMOUUAKORLOHCD-UHFFFAOYSA-N;MFCD09839392;AKOS015850534;FT-0685152;E80463;A883714;2-(Chloromethyl)-6-chloroimidazo[1,2-b]pyridazine;6-chloro-2-(chloromethyl) imidazo[1,2-b]pyridazine;A1-00175;W-205768;6-Chloro-2-chloromethyl imidazo [1,2-b] pyridazine;6-Chloro-2-chloromethylimidazo[1,2-b]pyridazine, AldrichCPR

Chemical Property of 6-Chloro-2-(chloromethyl)imidazo[1,2-b]pyridazine

Chemical Property:

• Melting Point: 157℃
• Refractive Index: 1.698
• Boiling Point: °Cat760mmHg
• PKA: 2.76±0.30(Predicted)
• Flash Point: °C
• PSA: 30.19000
• Density: 1.59g/cm³
• LogP: 2.12150
• XLogP3: 1.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 200.9860526
• Heavy Atom Count: 12
• Complexity: 167

Purity/Quality:

97% ^*data from raw suppliers

6-Chloro-2-chloromethylimidazo[1,2-B]pyridazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C,Xn
• Hazard Codes: C,Xn
• Statements: 34-22
• Safety Statements: 22-26-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=NN2C1=NC(=C2)CCl)Cl

Technology Process of 6-Chloro-2-(chloromethyl)imidazo[1,2-b]pyridazine

There total 2 articles about 6-Chloro-2-(chloromethyl)imidazo[1,2-b]pyridazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

6-chloro-pyridazin-3-ylamine (5469-69-2) + 1,3-Dichloroacetone (534-07-6) → 6-chloro-2-(chloromethyl)imidazo[1,2-b]pyridazine (154578-23-1)

Guidance literature:

6-chloro-pyridazin-3-ylamine; 1,3-Dichloroacetone; In ethanol; for 4h; Heating;

With sodium hydroxide;

DOI:10.1002/jhet.5570390125

Reference yield:

6-chloro-pyridazin-3-ylamine (5469-69-2) → 6-chloro-2-(chloromethyl)imidazo[1,2-b]pyridazine (154578-23-1)

Guidance literature:

Reference yield: 96.0%

1-(2-Methoxyphenyl)piperazine (35386-24-4) + 6-chloro-2-(chloromethyl)imidazo[1,2-b]pyridazine (154578-23-1) → 6-chloro-2-[4-(2-methoxy-phenyl)-piperazin-1-ylmethyl]-imidazo[1,2-b]pyridazine

Guidance literature:

With sodium carbonate; In ethanol; for 3h; Heating;

DOI:10.1021/jm060166w

upstream raw materials:

6-chloro-pyridazin-3-ylamine

1,3-Dichloroacetone

Downstream raw materials:

6-chloroimidazo[1,2-b]pyridazine-2-carbaldehyde

6-chloro-2-[4-(3,4-dichloro-phenyl)-piperazin-1-ylmethyl]-imidazo[1,2-b]pyridazine

2-benzyl-6-(thien-3-yl)imidazo[1,2-b]pyridazine

2-(4-fluorobenzyl)-6-(4-methoxyphenyl)imidazo[1,2-b]pyridazine