8-[3-[N-[(E)-3-(6-Carboxypyridin-3-yl)acryloylglycyl]-N-methylamino]-2,6-dichlorobenzyloxy]-2-methylquinoline

Base Information

Chemical Name:8-[3-[N-[(E)-3-(6-Carboxypyridin-3-yl)acryloylglycyl]-N-methylamino]-2,6-dichlorobenzyloxy]-2-methylquinoline
CAS No.:167838-69-9
Molecular Formula:C₂₉H₂₄Cl₂N₄O₅
Molecular Weight:579.439
Hs Code.:

Synonyms:8-[3-[N-[(E)-3-(6-Carboxypyridin-3-yl)acryloylglycyl]-N-methylamino]-2,6-dichlorobenzyloxy]-2-methylquinoline

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Chemical Property of 8-[3-[N-[(E)-3-(6-Carboxypyridin-3-yl)acryloylglycyl]-N-methylamino]-2,6-dichlorobenzyloxy]-2-methylquinoline

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Technology Process of 8-[3-[N-[(E)-3-(6-Carboxypyridin-3-yl)acryloylglycyl]-N-methylamino]-2,6-dichlorobenzyloxy]-2-methylquinoline

There total 12 articles about 8-[3-[N-[(E)-3-(6-Carboxypyridin-3-yl)acryloylglycyl]-N-methylamino]-2,6-dichlorobenzyloxy]-2-methylquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 167838-45-1
8-[2,6-Dichloro-3-[N-[(E)-3-(6-ethoxycarbonylpyridin-3-yl)acryloylglycyl]-N-methylamino]benzyloxy]-2-methylquinoline

: 167838-69-9
8-[3-[N-[(E)-3-(6-Carboxypyridin-3-yl)acryloylglycyl]-N-methylamino]-2,6-dichlorobenzyloxy]-2-methylquinoline

Guidance literature:: With sodium hydroxide; In ethanol;
DOI:10.1021/jm980300f

Reference yield:

: 826-81-3
2-methyl-8-quinolinol

: 167838-69-9
8-[3-[N-[(E)-3-(6-Carboxypyridin-3-yl)acryloylglycyl]-N-methylamino]-2,6-dichlorobenzyloxy]-2-methylquinoline

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) NaH / 1.) DMF, 0 deg C, 30 min, 2.) DMF, RT, 2 h

2: hydrazine hydrate / ethanol / 1 h / Heating

3: WSCD*HCl, HOBt / dimethylformamide / 2 h / Ambient temperature

4: 1 N NaOH / ethanol

With sodium hydroxide; WSCD*HCl; sodium hydride; benzotriazol-1-ol; hydrazine hydrate; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm980300f

Reference yield:

: 160647-01-8
2,6-Dichloro-3-nitrobenzyl alcohol

: 167838-69-9
8-[3-[N-[(E)-3-(6-Carboxypyridin-3-yl)acryloylglycyl]-N-methylamino]-2,6-dichlorobenzyloxy]-2-methylquinoline

Guidance literature:: Multi-step reaction with 10 steps

1: 81.5 percent / imidazole / dimethylformamide / 3 h / Ambient temperature

2: FeCl₃*6H₂O, C, NH₂-NH₂*H₂O / methanol; H₂O / 5 h / 70 °C

3: 89.3 percent / Et₃N / CH₂Cl₂ / 1.5 h / 0 - 20 °C

4: 1.) NaH / 1.) DMF, 0 deg C, 30 min, 2.) DMF, RT, 2 h

5: TBAF / tetrahydrofuran / 1 h / Ambient temperature

6: Et₃N / CH₂Cl₂ / 0.5 h

7: 1.) NaH / 1.) DMF, 0 deg C, 30 min, 2.) DMF, RT, 2 h

8: hydrazine hydrate / ethanol / 1 h / Heating

9: WSCD*HCl, HOBt / dimethylformamide / 2 h / Ambient temperature

10: 1 N NaOH / ethanol

With 1H-imidazole; sodium hydroxide; WSCD*HCl; tetrabutyl ammonium fluoride; iron(III) chloride; sodium hydride; benzotriazol-1-ol; hydrazine hydrate; triethylamine; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm980300f