3',6'-bis((4,5-dimethoxy-2-nitrobenzyl)oxy)-2',7'-difluoro-3-oxo-3H-spiro[isobenzofuran-1,9'-xanthene]-5-carboxylic acid

Base Information

Chemical Name:3',6'-bis((4,5-dimethoxy-2-nitrobenzyl)oxy)-2',7'-difluoro-3-oxo-3H-spiro[isobenzofuran-1,9'-xanthene]-5-carboxylic acid
CAS No.:1352809-14-3
Molecular Formula:C₃₉H₂₈F₂N₂O₁₅
Molecular Weight:802.653
Hs Code.:

Synonyms:3',6'-bis((4,5-dimethoxy-2-nitrobenzyl)oxy)-2',7'-difluoro-3-oxo-3H-spiro[isobenzofuran-1,9'-xanthene]-5-carboxylic acid

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Chemical Property of 3',6'-bis((4,5-dimethoxy-2-nitrobenzyl)oxy)-2',7'-difluoro-3-oxo-3H-spiro[isobenzofuran-1,9'-xanthene]-5-carboxylic acid

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Technology Process of 3',6'-bis((4,5-dimethoxy-2-nitrobenzyl)oxy)-2',7'-difluoro-3-oxo-3H-spiro[isobenzofuran-1,9'-xanthene]-5-carboxylic acid

There total 5 articles about 3',6'-bis((4,5-dimethoxy-2-nitrobenzyl)oxy)-2',7'-difluoro-3-oxo-3H-spiro[isobenzofuran-1,9'-xanthene]-5-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1352809-13-2
bis(2,4-dimethoxybenzyl) 4-(3,6-bis((4,5-dimethoxy-2-nitrobenzyl)oxy)-2,7-difluoro-9H-xanthen-9-yl)isophthalate

: 1352809-14-3
3',6'-bis((4,5-dimethoxy-2-nitrobenzyl)oxy)-2',7'-difluoro-3-oxo-3H-spiro[isobenzofuran-1,9'-xanthene]-5-carboxylic acid

Guidance literature:: With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In dichloromethane; water; at 20 ℃; for 24h; Darkness;
DOI:10.1002/anie.201104571

Reference yield:

: 1352809-12-1
bis(2,4-dimethoxybenzyl) 4-(2,7-difluoro-3,6-dihydroxy-9H-xanthen-9-yl)isophthalate

: 1352809-14-3
3',6'-bis((4,5-dimethoxy-2-nitrobenzyl)oxy)-2',7'-difluoro-3-oxo-3H-spiro[isobenzofuran-1,9'-xanthene]-5-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate / dichloromethane; water / 18 h / 20 °C / Darkness

2: 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane; water / 24 h / 20 °C / Darkness

With tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In dichloromethane; water;
DOI:10.1002/anie.201104571

Reference yield:

: 1352809-16-5
C₂₅H₁₆F₂O₉

: 1352809-14-3
3',6'-bis((4,5-dimethoxy-2-nitrobenzyl)oxy)-2',7'-difluoro-3-oxo-3H-spiro[isobenzofuran-1,9'-xanthene]-5-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: diisopropyl-carbodiimide / dichloromethane / 18 h / 20 °C

2: ammonium bicarbonate / tetrahydrofuran; methanol; water / 24 h / 20 °C / Darkness

3: tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate / dichloromethane; water / 18 h / 20 °C / Darkness

4: 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane; water / 24 h / 20 °C / Darkness

With tetra(n-butyl)ammonium hydrogensulfate; ammonium bicarbonate; potassium carbonate; 2,3-dicyano-5,6-dichloro-p-benzoquinone; diisopropyl-carbodiimide; In tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1002/anie.201104571