bis(2,4-dimethoxybenzyl) 4-(3,6-diacetoxy-2,7-difluoro-9H-xanthen-9-yl)isophthalate

Base Information

• Chemical Name: bis(2,4-dimethoxybenzyl) 4-(3,6-diacetoxy-2,7-difluoro-9H-xanthen-9-yl)isophthalate
• CAS No.: 1352809-11-0
• Molecular Formula: C₄₃H₃₆F₂O₁₃
• Molecular Weight: 798.748

Synonyms:bis(2,4-dimethoxybenzyl) 4-(3,6-diacetoxy-2,7-difluoro-9H-xanthen-9-yl)isophthalate

Chemical Property of bis(2,4-dimethoxybenzyl) 4-(3,6-diacetoxy-2,7-difluoro-9H-xanthen-9-yl)isophthalate

Chemical Property:

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Technology Process of bis(2,4-dimethoxybenzyl) 4-(3,6-diacetoxy-2,7-difluoro-9H-xanthen-9-yl)isophthalate

There total 2 articles about bis(2,4-dimethoxybenzyl) 4-(3,6-diacetoxy-2,7-difluoro-9H-xanthen-9-yl)isophthalate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

2,4-dimethoxylbenzyl alcohol (7314-44-5) + C25H16F2O9 (1352809-16-5) → bis(2,4-dimethoxybenzyl) 4-(3,6-diacetoxy-2,7-difluoro-9H-xanthen-9-yl)isophthalate (1352809-11-0)

Guidance literature:

With diisopropyl-carbodiimide; In dichloromethane; at 20 ℃; for 18h;

DOI:10.1002/anie.201104571

Reference yield:

3',6'-diacetoxy-2',7'-difluoro-3-oxo-3H-spiro[isobenzofuran-1,9'-xanthene]-5-carboxylic acid (195136-74-4) → bis(2,4-dimethoxybenzyl) 4-(3,6-diacetoxy-2,7-difluoro-9H-xanthen-9-yl)isophthalate (1352809-11-0)

Guidance literature:

Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 16 h / 20 °C / 760.05 Torr

2: diisopropyl-carbodiimide / dichloromethane / 18 h / 20 °C

With palladium 10% on activated carbon; hydrogen; diisopropyl-carbodiimide; In dichloromethane; ethyl acetate;

DOI:10.1002/anie.201104571

Reference yield: 98.0%

bis(2,4-dimethoxybenzyl) 4-(3,6-diacetoxy-2,7-difluoro-9H-xanthen-9-yl)isophthalate (1352809-11-0) → bis(2,4-dimethoxybenzyl) 4-(2,7-difluoro-3,6-dihydroxy-9H-xanthen-9-yl)isophthalate (1352809-12-1)

Guidance literature:

With ammonium bicarbonate; In tetrahydrofuran; methanol; water; at 20 ℃; for 24h; Darkness;

DOI:10.1002/anie.201104571

upstream raw materials:

2,4-dimethoxylbenzyl alcohol

C₂₅H₁₆F₂O₉

3',6'-diacetoxy-2',7'-difluoro-3-oxo-3H-spiro[isobenzofuran-1,9'-xanthene]-5-carboxylic acid

Downstream raw materials:

bis(2,4-dimethoxybenzyl) 4-(2,7-difluoro-3,6-dihydroxy-9H-xanthen-9-yl)isophthalate

bis(2,4-dimethoxybenzyl) 4-(3,6-bis((4,5-dimethoxy-2-nitrobenzyl)oxy)-2,7-difluoro-9H-xanthen-9-yl)isophthalate

3',6'-bis((4,5-dimethoxy-2-nitrobenzyl)oxy)-2',7'-difluoro-3-oxo-3H-spiro[isobenzofuran-1,9'-xanthene]-5-carboxylic acid

NV₂-2',7'-difluorofluorescein-5-PEG₂-biotin

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