(E)-<2,3-bis(4-fluorophenyl)-5-(1-methylethyl)-1H-pyrrol-1-yl>-2-propenoic acid methyl ester

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Chemical Name:(E)-<2,3-bis(4-fluorophenyl)-5-(1-methylethyl)-1H-pyrrol-1-yl>-2-propenoic acid methyl ester
CAS No.:151105-88-3
Molecular Formula:C₂₃H₂₁F₂NO₂
Molecular Weight:381.422
Hs Code.:

Synonyms:(E)-<2,3-bis(4-fluorophenyl)-5-(1-methylethyl)-1H-pyrrol-1-yl>-2-propenoic acid methyl ester

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Chemical Property of (E)-<2,3-bis(4-fluorophenyl)-5-(1-methylethyl)-1H-pyrrol-1-yl>-2-propenoic acid methyl ester

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Technology Process of (E)-<2,3-bis(4-fluorophenyl)-5-(1-methylethyl)-1H-pyrrol-1-yl>-2-propenoic acid methyl ester

There total 4 articles about (E)-<2,3-bis(4-fluorophenyl)-5-(1-methylethyl)-1H-pyrrol-1-yl>-2-propenoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 53458-16-5
1,2-bis(4-fluorophenyl)-2-hydroxyethan-1-one

: 151105-88-3
(E)-<2,3-bis(4-fluorophenyl)-5-(1-methylethyl)-1H-pyrrol-1-yl>-2-propenoic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 70 percent / ammonium acetate, AcOH / 2 h / Heating

2: 91 percent / 80percent aq. H₂SO₄ / 0.25 h / 110 °C

3: 1.) NaH / 1.) DMF, 10 min, 2.) DMF, 20 deg C, 1 h

With ammonium acetate; sulfuric acid; sodium hydride; acetic acid;
DOI:10.1021/jm00075a021

Reference yield:

: 366-68-7
4,4'-difluorodeoxybenzoin

: 151105-88-3
(E)-<2,3-bis(4-fluorophenyl)-5-(1-methylethyl)-1H-pyrrol-1-yl>-2-propenoic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) sodium bis(trimethylsilyl)amide, 2.) chlorotrimethylsilane, 3.) m-chloroperbenzoic acid, 4.) aq. HCl

2: 70 percent / ammonium acetate, AcOH / 2 h / Heating

3: 91 percent / 80percent aq. H₂SO₄ / 0.25 h / 110 °C

4: 1.) NaH / 1.) DMF, 10 min, 2.) DMF, 20 deg C, 1 h

With ammonium acetate; hydrogenchloride; chloro-trimethyl-silane; sulfuric acid; sodium hexamethyldisilazane; sodium hydride; acetic acid; 3-chloro-benzenecarboperoxoic acid;
DOI:10.1021/jm00075a021

Reference yield:

: 151105-81-6
4,5-bis(4-fluorophenyl)-2-(1-methylethyl)-1H-pyrrole-3-carboxylic acid ethyl ester

: 151105-88-3
(E)-<2,3-bis(4-fluorophenyl)-5-(1-methylethyl)-1H-pyrrol-1-yl>-2-propenoic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 91 percent / 80percent aq. H₂SO₄ / 0.25 h / 110 °C

2: 1.) NaH / 1.) DMF, 10 min, 2.) DMF, 20 deg C, 1 h

With sulfuric acid; sodium hydride;
DOI:10.1021/jm00075a021