Technology Process of 5,5-diethyl-2-phenethyl-2-(trimethylsilyl)-1,3-dithiane 1,1-dioxide
There total 5 articles about 5,5-diethyl-2-phenethyl-2-(trimethylsilyl)-1,3-dithiane 1,1-dioxide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
5,5-diethyl-2-phenethyl-1,3-dithiane-1,1-dioxide;
With
n-butyllithium;
In
tetrahydrofuran; hexane;
at -63 - -30 ℃;
for 1.13333h;
Schlenk technique;
Inert atmosphere;
chloro-trimethyl-silane;
In
tetrahydrofuran; hexane;
at -30 - 20 ℃;
Schlenk technique;
Inert atmosphere;
DOI:10.1021/ol403041k
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: boron trifluoride diethyl etherate / dichloromethane / 1.03 h / 0 - 25 °C / Inert atmosphere
2.1: sodium periodate / methanol; water / 1.75 h / 0 - 20 °C / Inert atmosphere
3.1: magnesium sulfate; tetrabutylammomium bromide; potassium permanganate / dichloromethane; water / 18 h / 20 °C / Inert atmosphere
4.1: n-butyllithium / tetrahydrofuran; hexane / 1.13 h / -63 - -30 °C / Schlenk technique; Inert atmosphere
4.2: -30 - 20 °C / Schlenk technique; Inert atmosphere
With
potassium permanganate; sodium periodate; n-butyllithium; boron trifluoride diethyl etherate; tetrabutylammomium bromide; magnesium sulfate;
In
tetrahydrofuran; methanol; hexane; dichloromethane; water;
DOI:10.1021/ol403041k
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium periodate / methanol; water / 1.75 h / 0 - 20 °C / Inert atmosphere
2.1: magnesium sulfate; tetrabutylammomium bromide; potassium permanganate / dichloromethane; water / 18 h / 20 °C / Inert atmosphere
3.1: n-butyllithium / tetrahydrofuran; hexane / 1.13 h / -63 - -30 °C / Schlenk technique; Inert atmosphere
3.2: -30 - 20 °C / Schlenk technique; Inert atmosphere
With
potassium permanganate; sodium periodate; n-butyllithium; tetrabutylammomium bromide; magnesium sulfate;
In
tetrahydrofuran; methanol; hexane; dichloromethane; water;
DOI:10.1021/ol403041k
