2-(but-3-enyl)-3,3-dimethylcyclohexanone

Base Information

• Chemical Name: 2-(but-3-enyl)-3,3-dimethylcyclohexanone
• CAS No.: 124941-48-6
• Molecular Formula: C₁₂H₂₀O
• Molecular Weight: 180.29
• Mol file: 124941-48-6.mol

Synonyms:2-(but-3-enyl)-3,3-dimethylcyclohexanone

Chemical Property of 2-(but-3-enyl)-3,3-dimethylcyclohexanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(but-3-enyl)-3,3-dimethylcyclohexanone

There total 8 articles about 2-(but-3-enyl)-3,3-dimethylcyclohexanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

methyl magnesium iodide (917-64-6) + 3-methyl-2-(3-butenyl)-cyclohex-2-en-1-on (2658-92-6) → 2-(but-3-enyl)-3,3-dimethylcyclohexanone (124941-48-6)

Guidance literature:

With copper(I) bromide dimethylsulfide complex; In diethyl ether; at -78 ℃;

DOI:10.1246/cl.1999.51

Reference yield:

C15H28OSi → 2-(but-3-enyl)-3,3-dimethylcyclohexanone (124941-48-6)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 0.5h; Inert atmosphere;

DOI:10.1021/ja300369c

Reference yield:

methyl 2-methyl-4-oxocyclohex-2-enecarboxylate (35490-07-4,134209-76-0) → 2-(but-3-enyl)-3,3-dimethylcyclohexanone (124941-48-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 93 percent / NaH / toluene

2: 50 percent / KOH / methanol / 24 h

3: 94 percent / CuBr*S(CH₃)2 / diethyl ether / -78 °C

With potassium hydroxide; copper(I) bromide dimethylsulfide complex; sodium hydride; In methanol; diethyl ether; toluene;

DOI:10.1246/cl.1999.51

upstream raw materials:

methyl magnesium iodide

3-methyl-2-(3-butenyl)-cyclohex-2-en-1-on

methyl 2-methyl-4-oxocyclohex-2-enecarboxylate

4-methyl-6-oxo-cyclohex-4-ene-1,3-dicarboxylic acid dimethyl ester

Downstream raw materials:

(E)-2-(5-azidopent-3-enyl)-3,3-dimethylcyclohexanone