3-[(2S,5R)-5-hydroxy-1-(toluene-4-sulphonyl)piperidin-2-yl]-2,2-dimethylpropionic acid methyl ester

Base Information

Chemical Name:3-[(2S,5R)-5-hydroxy-1-(toluene-4-sulphonyl)piperidin-2-yl]-2,2-dimethylpropionic acid methyl ester
CAS No.:959937-56-5
Molecular Formula:C₁₈H₂₇NO₅S
Molecular Weight:369.482
Hs Code.:

Synonyms:3-[(2S,5R)-5-hydroxy-1-(toluene-4-sulphonyl)piperidin-2-yl]-2,2-dimethylpropionic acid methyl ester

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Chemical Property of 3-[(2S,5R)-5-hydroxy-1-(toluene-4-sulphonyl)piperidin-2-yl]-2,2-dimethylpropionic acid methyl ester

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Technology Process of 3-[(2S,5R)-5-hydroxy-1-(toluene-4-sulphonyl)piperidin-2-yl]-2,2-dimethylpropionic acid methyl ester

There total 1 articles about 3-[(2S,5R)-5-hydroxy-1-(toluene-4-sulphonyl)piperidin-2-yl]-2,2-dimethylpropionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 959937-57-6
3-[(2S,5R)-5-(4-methoxybenzyloxy)-1-(toluene-4-sulphonyl)piperidin-2-yl]-2,2-dimethylpropionic acid methyl ester

: 959937-56-5
3-[(2S,5R)-5-hydroxy-1-(toluene-4-sulphonyl)piperidin-2-yl]-2,2-dimethylpropionic acid methyl ester

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In methanol; for 16h;

Reference yield:

: 857272-02-7
6-chloromethyl-4-(3-methoxy-propyl)-4H-benzo[1,4]oxazin-3-one

: 959937-56-5
3-[(2S,5R)-5-hydroxy-1-(toluene-4-sulphonyl)piperidin-2-yl]-2,2-dimethylpropionic acid methyl ester

: 959937-54-3
methyl 3-[(2S,5R)-5-[4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-1-(toluene-4-sulphonyl)piperidin-2-yl]-2,2-dimethylpropionate

Guidance literature:: 6-chloromethyl-4-(3-methoxy-propyl)-4H-benzo[1,4]oxazin-3-one; 3-[(2S,5R)-5-hydroxy-1-(toluene-4-sulphonyl)piperidin-2-yl]-2,2-dimethylpropionic acid methyl ester; With tetra-(n-butyl)ammonium iodide; In N,N-dimethyl-formamide; at 20 ℃; for 0.25h;

With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 3h; Product distribution / selectivity;

Reference yield:

: 959937-56-5
3-[(2S,5R)-5-hydroxy-1-(toluene-4-sulphonyl)piperidin-2-yl]-2,2-dimethylpropionic acid methyl ester

: 959937-92-9
2-[(2S,5R)-5-[4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-1-(toluene-4-sulphonyl)piperidin-2-yl]-1,1-dimethyl-ethylamine

Guidance literature:: Multi-step reaction with 7 steps

1.1: tetra-(n-butyl)ammonium iodide / N,N-dimethyl-formamide / 0.25 h / 20 °C

1.2: 3 h / 20 °C

2.1: methanol; sodium hydroxide; water / tetrahydrofuran / 4 h / 20 - 60 °C

2.2: 20 °C

3.1: triethylamine / tetrahydrofuran / 1 h / 0 °C

4.1: sodium azide / tetrahydrofuran; water / 0.75 h / 0 °C

5.1: toluene / 2 h / 115 °C

6.1: 2 h / 120 °C

7.1: hydrogen / palladium on activated charcoal / methanol / 2 h / 20 °C

With methanol; sodium hydroxide; sodium azide; water; hydrogen; tetra-(n-butyl)ammonium iodide; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; toluene;