N-(1,2-bis(4-isopropoxy-3-methoxyphenyl)-2-oxoethyl)-1-methyl-1H-indole-2-carboxamide

Base Information

Chemical Name:N-(1,2-bis(4-isopropoxy-3-methoxyphenyl)-2-oxoethyl)-1-methyl-1H-indole-2-carboxamide
CAS No.:1333109-45-7
Molecular Formula:C₃₂H₃₆N₂O₆
Molecular Weight:544.648
Hs Code.:

Synonyms:N-(1,2-bis(4-isopropoxy-3-methoxyphenyl)-2-oxoethyl)-1-methyl-1H-indole-2-carboxamide

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Chemical Property of N-(1,2-bis(4-isopropoxy-3-methoxyphenyl)-2-oxoethyl)-1-methyl-1H-indole-2-carboxamide

Chemical Property:

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Technology Process of N-(1,2-bis(4-isopropoxy-3-methoxyphenyl)-2-oxoethyl)-1-methyl-1H-indole-2-carboxamide

There total 8 articles about N-(1,2-bis(4-isopropoxy-3-methoxyphenyl)-2-oxoethyl)-1-methyl-1H-indole-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₆H₁₂N₄O₂

: 1333109-40-2
2-amino-1,2-bis(4-isopropoxy-3-methoxyphenyl)ethanone trifluoroacetate

: 1333109-45-7
N-(1,2-bis(4-isopropoxy-3-methoxyphenyl)-2-oxoethyl)-1-methyl-1H-indole-2-carboxamide

Guidance literature:: With triethylamine; In tetrahydrofuran; at 20 ℃; for 14h; Inert atmosphere;
DOI:10.1016/j.bmc.2011.06.056

Reference yield:

: 4-isopropoxy-3-methoxybenzoic acid isopropyl ester

: 1333109-45-7
N-(1,2-bis(4-isopropoxy-3-methoxyphenyl)-2-oxoethyl)-1-methyl-1H-indole-2-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium hydroxide / ethanol; water / 4 h / Reflux

1.2: pH 3

2.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran / 24 h / 20 °C / Inert atmosphere

3.1: dmap / acetonitrile / 16 h / 20 °C / Inert atmosphere

4.1: 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; lithium diisopropyl amide / tetrahydrofuran; hexane / 8 h / -78 °C / Inert atmosphere

5.1: dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

6.1: triethylamine / tetrahydrofuran / 14 h / 20 °C / Inert atmosphere

With dmap; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; potassium hydroxide; lithium diisopropyl amide; In tetrahydrofuran; ethanol; hexane; dichloromethane; water; acetonitrile;
DOI:10.1016/j.bmc.2011.06.056

Reference yield:

: 1333109-36-6
N-(4-isopropoxy-3-methoxybenzyl)-4-isopropoxy-3-methoxybenzamide

: 1333109-45-7
N-(1,2-bis(4-isopropoxy-3-methoxyphenyl)-2-oxoethyl)-1-methyl-1H-indole-2-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: dmap / acetonitrile / 16 h / 20 °C / Inert atmosphere

2: 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; lithium diisopropyl amide / tetrahydrofuran; hexane / 8 h / -78 °C / Inert atmosphere

3: dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

4: triethylamine / tetrahydrofuran / 14 h / 20 °C / Inert atmosphere

With dmap; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; hexane; dichloromethane; acetonitrile;
DOI:10.1016/j.bmc.2011.06.056