4-chloromethyl-5-methyl-2-[4-(2,2,2-trifluoro-ethoxy)-phenyl]-oxazole

Base Information

• Chemical Name: 4-chloromethyl-5-methyl-2-[4-(2,2,2-trifluoro-ethoxy)-phenyl]-oxazole
• CAS No.: 1025984-75-1
• Molecular Formula: C₁₃H₁₁ClF₃NO₂
• Molecular Weight: 305.684

Synonyms:4-chloromethyl-5-methyl-2-[4-(2,2,2-trifluoro-ethoxy)-phenyl]-oxazole

Chemical Property of 4-chloromethyl-5-methyl-2-[4-(2,2,2-trifluoro-ethoxy)-phenyl]-oxazole

Chemical Property:

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Technology Process of 4-chloromethyl-5-methyl-2-[4-(2,2,2-trifluoro-ethoxy)-phenyl]-oxazole

There total 2 articles about 4-chloromethyl-5-methyl-2-[4-(2,2,2-trifluoro-ethoxy)-phenyl]-oxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4,5-dimethyl-2-[4-(2,2,2-trifluoro-ethoxy)-phenyl]-oxazole 3-oxide (1026724-01-5) → 4-chloromethyl-5-methyl-2-[4-(2,2,2-trifluoro-ethoxy)-phenyl]-oxazole (1025984-75-1)

Guidance literature:

With trichlorophosphate; In chloroform; for 2.5h; Heating;

DOI:10.1021/jm990476x

Reference yield:

4-(2,2,2-trifluoroethoxy)benzaldehyde (76579-46-9) → 4-chloromethyl-5-methyl-2-[4-(2,2,2-trifluoro-ethoxy)-phenyl]-oxazole (1025984-75-1)

Guidance literature:

Multi-step reaction with 2 steps

1: HCl gas / ethyl acetate / 3 h / 5 °C

2: POCl₃ / CHCl₃ / 2.5 h / Heating

With hydrogenchloride; trichlorophosphate; In chloroform; ethyl acetate; 1: Condensation / 2: Chlorination;

DOI:10.1021/jm990476x

Reference yield:

3-Hydroxyacetophenone (121-71-1) + 4-chloromethyl-5-methyl-2-[4-(2,2,2-trifluoro-ethoxy)-phenyl]-oxazole (1025984-75-1) → 1-(3-{5-methyl-2-[4-(2,2,2-trifluoro-ethoxy)-phenyl]-oxazol-4-ylmethoxy}-phenyl)-ethanone

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 65 ℃; for 10h;

DOI:10.1021/jm990476x

upstream raw materials:

4,5-dimethyl-2-[4-(2,2,2-trifluoro-ethoxy)-phenyl]-oxazole 3-oxide

4-(2,2,2-trifluoroethoxy)benzaldehyde

Downstream raw materials:

4-[3-((E)-3-Chloro-1-methyl-propenyl)-phenoxymethyl]-5-methyl-2-[4-(2,2,2-trifluoro-ethoxy)-phenyl]-oxazole

(E)-3-(3-{5-Methyl-2-[4-(2,2,2-trifluoro-ethoxy)-phenyl]-oxazol-4-ylmethoxy}-phenyl)-but-2-en-1-ol

(E)-3-(3-{5-Methyl-2-[4-(2,2,2-trifluoro-ethoxy)-phenyl]-oxazol-4-ylmethoxy}-phenyl)-but-2-enoic acid ethyl ester

N-[3-(3-{5-methyl-2-[4-(2,2,2-trifluoro-ethoxy)-phenyl]-oxazol-4-ylmethoxy}-phenyl)-but-2-enyl]-hydroxylamine

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