1,1-difluoro-1-[2-fluoro-6-(8-fluoroquinolin-3-yloxy)-phenyl]-2-methyl-propan-2-ol

Base Information

Chemical Name:1,1-difluoro-1-[2-fluoro-6-(8-fluoroquinolin-3-yloxy)-phenyl]-2-methyl-propan-2-ol
CAS No.:1314009-98-7
Molecular Formula:C₁₉H₁₅F₄NO₂
Molecular Weight:365.327
Hs Code.:

Synonyms:1,1-difluoro-1-[2-fluoro-6-(8-fluoroquinolin-3-yloxy)-phenyl]-2-methyl-propan-2-ol

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Chemical Property of 1,1-difluoro-1-[2-fluoro-6-(8-fluoroquinolin-3-yloxy)-phenyl]-2-methyl-propan-2-ol

Chemical Property:

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Technology Process of 1,1-difluoro-1-[2-fluoro-6-(8-fluoroquinolin-3-yloxy)-phenyl]-2-methyl-propan-2-ol

There total 3 articles about 1,1-difluoro-1-[2-fluoro-6-(8-fluoroquinolin-3-yloxy)-phenyl]-2-methyl-propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1314009-97-6
difluoro[2-fluoro-6-(8-fluoroquinolin-3-yloxy)] ethyl acetate

: 676-58-4
methylmagnesium chloride

: 1314009-98-7
1,1-difluoro-1-[2-fluoro-6-(8-fluoroquinolin-3-yloxy)-phenyl]-2-methyl-propan-2-ol

Guidance literature:: difluoro[2-fluoro-6-(8-fluoroquinolin-3-yloxy)] ethyl acetate; methylmagnesium chloride; In tetrahydrofuran; at 0 ℃; for 2h;

With hydrogenchloride; In tetrahydrofuran; water;

Reference yield:

: 13697-89-7
2,6-difluoroiodobenzene

: 1314009-98-7
1,1-difluoro-1-[2-fluoro-6-(8-fluoroquinolin-3-yloxy)-phenyl]-2-methyl-propan-2-ol

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / 1-methyl-pyrrolidin-2-one / 24 h / 130 °C

2: copper / dimethyl sulfoxide / 24 h / 40 °C

3: tetrahydrofuran / 2 h / 0 °C

With copper; potassium carbonate; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; dimethyl sulfoxide;

Reference yield:

: 1261784-49-9
8-fluoro-3-hydroxyquinoline

: 1314009-98-7
1,1-difluoro-1-[2-fluoro-6-(8-fluoroquinolin-3-yloxy)-phenyl]-2-methyl-propan-2-ol

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / 1-methyl-pyrrolidin-2-one / 24 h / 130 °C

2: copper / dimethyl sulfoxide / 24 h / 40 °C

3: tetrahydrofuran / 2 h / 0 °C

With copper; potassium carbonate; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; dimethyl sulfoxide;