2-(3-((4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)hexahydropyrano[3,4-c]pyrrol-4(2H)-one

Base Information

Chemical Name:2-(3-((4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)hexahydropyrano[3,4-c]pyrrol-4(2H)-one
CAS No.:1438072-95-7
Molecular Formula:C₂₅H₂₆ClFN₄O₄
Molecular Weight:500.957
Hs Code.:

Synonyms:2-(3-((4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)hexahydropyrano[3,4-c]pyrrol-4(2H)-one

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Chemical Property of 2-(3-((4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)hexahydropyrano[3,4-c]pyrrol-4(2H)-one

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Technology Process of 2-(3-((4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)hexahydropyrano[3,4-c]pyrrol-4(2H)-one

There total 11 articles about 2-(3-((4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)hexahydropyrano[3,4-c]pyrrol-4(2H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 19.62%

: 1438081-44-7
2-(3-chloropropyl)hexahydropyrano[3,4-c]pyrrol-4(2H)-one

: 184475-71-6
4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline

: 1438072-95-7
2-(3-((4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)hexahydropyrano[3,4-c]pyrrol-4(2H)-one

Guidance literature:: With tetra-(n-butyl)ammonium iodide; potassium carbonate; In N,N-dimethyl-formamide; at 90 ℃; for 20h;

Reference yield:

: 230955-75-6
6-acetoxy-4-chloro-7-methoxyquinazoline

: 1438072-95-7
2-(3-((4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)hexahydropyrano[3,4-c]pyrrol-4(2H)-one

Guidance literature:: Multi-step reaction with 3 steps

1: isopropyl alcohol / 5 h / 88 °C

2: water; sodium hydroxide / methanol / 6 h / 20 °C

3: potassium carbonate; tetra-(n-butyl)ammonium iodide / N,N-dimethyl-formamide / 20 h / 90 °C

With water; tetra-(n-butyl)ammonium iodide; potassium carbonate; sodium hydroxide; In methanol; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 179688-53-0
6-acetoxy-7-methoxy-3,4-dihydroquinazolin-4-one

: 1438072-95-7
2-(3-((4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)hexahydropyrano[3,4-c]pyrrol-4(2H)-one

Guidance literature:: Multi-step reaction with 4 steps

1: thionyl chloride / N,N-dimethyl-formamide / 3 h / 70 °C

2: isopropyl alcohol / 5 h / 88 °C

3: water; sodium hydroxide / methanol / 6 h / 20 °C

4: potassium carbonate; tetra-(n-butyl)ammonium iodide / N,N-dimethyl-formamide / 20 h / 90 °C

With thionyl chloride; water; tetra-(n-butyl)ammonium iodide; potassium carbonate; sodium hydroxide; In methanol; N,N-dimethyl-formamide; isopropyl alcohol;