4-[[3,3-difluoro-3-(4-fluorophenyl)propyl]sulfanyl]pyridine-3-carboxylic acid

Base Information

Chemical Name:4-[[3,3-difluoro-3-(4-fluorophenyl)propyl]sulfanyl]pyridine-3-carboxylic acid
CAS No.:1610889-91-2
Molecular Formula:C₁₅H₁₂F₃NO₂S
Molecular Weight:327.327
Hs Code.:

Synonyms:4-[[3,3-difluoro-3-(4-fluorophenyl)propyl]sulfanyl]pyridine-3-carboxylic acid

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Chemical Property of 4-[[3,3-difluoro-3-(4-fluorophenyl)propyl]sulfanyl]pyridine-3-carboxylic acid

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Technology Process of 4-[[3,3-difluoro-3-(4-fluorophenyl)propyl]sulfanyl]pyridine-3-carboxylic acid

There total 9 articles about 4-[[3,3-difluoro-3-(4-fluorophenyl)propyl]sulfanyl]pyridine-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 67-56-1
methanol

: 1242643-05-5
1-(3-bromo-1,1-difluoropropyl)-4-fluorobenzene

: 1610889-89-8
4-(2-methoxycarbonylethylsulfanyl)pyridine-3-carboxylic acid ethyl ester

: 1610889-91-2
4-[[3,3-difluoro-3-(4-fluorophenyl)propyl]sulfanyl]pyridine-3-carboxylic acid

Guidance literature:: methanol; 4-(2-methoxycarbonylethylsulfanyl)pyridine-3-carboxylic acid ethyl ester; With sodium; at 70 ℃; for 1.5h;

1-(3-bromo-1,1-difluoropropyl)-4-fluorobenzene; With potassium carbonate; In acetone; at 70 ℃; for 2.5h;

With water; sodium hydroxide; In ethanol; at 20 ℃; for 2h;

Reference yield:

: 66267-03-6
acetic acid [3-(4-fluorophenyl)-3-oxopropyl] ester

: 1610889-91-2
4-[[3,3-difluoro-3-(4-fluorophenyl)propyl]sulfanyl]pyridine-3-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: boron trifluoride diethyl etherate / dichloromethane / 6 h / 0 - 20 °C

2.1: 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; pyridine hydrofluoride / dichloromethane / 3.5 h / -78 - 20 °C

3.1: water; sodium hydroxide / ethanol / 1 h / 0 - 20 °C

4.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 1 h / 0 - 20 °C

5.1: sodium / 1.5 h / 70 °C

5.2: 2.5 h / 70 °C

5.3: 2 h / 20 °C

With 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; carbon tetrabromide; pyridine hydrofluoride; boron trifluoride diethyl etherate; water; sodium; triphenylphosphine; sodium hydroxide; In ethanol; dichloromethane;

Reference yield:

: 1242643-02-2
acetic acid 2-[2-(4-fluorophenyl)-[1,3]dithiolan-2-yl]ethyl ester

: 1610889-91-2
4-[[3,3-difluoro-3-(4-fluorophenyl)propyl]sulfanyl]pyridine-3-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; pyridine hydrofluoride / dichloromethane / 3.5 h / -78 - 20 °C

2.1: water; sodium hydroxide / ethanol / 1 h / 0 - 20 °C

3.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 1 h / 0 - 20 °C

4.1: sodium / 1.5 h / 70 °C

4.2: 2.5 h / 70 °C

4.3: 2 h / 20 °C

With 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; carbon tetrabromide; pyridine hydrofluoride; water; sodium; triphenylphosphine; sodium hydroxide; In ethanol; dichloromethane;