dimethyl (S)-2-{N-benzyl-N-[2-(benzyloxycarbonylamino)acetyl]amino}pentanedioate

Base Information

Chemical Name:dimethyl (S)-2-{N-benzyl-N-[2-(benzyloxycarbonylamino)acetyl]amino}pentanedioate
CAS No.:433285-17-7
Molecular Formula:C₂₄H₂₈N₂O₇
Molecular Weight:456.496
Hs Code.:

Synonyms:dimethyl (S)-2-{N-benzyl-N-[2-(benzyloxycarbonylamino)acetyl]amino}pentanedioate

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Chemical Property of dimethyl (S)-2-{N-benzyl-N-[2-(benzyloxycarbonylamino)acetyl]amino}pentanedioate

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Technology Process of dimethyl (S)-2-{N-benzyl-N-[2-(benzyloxycarbonylamino)acetyl]amino}pentanedioate

There total 5 articles about dimethyl (S)-2-{N-benzyl-N-[2-(benzyloxycarbonylamino)acetyl]amino}pentanedioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 1138-80-3
N-(Benzyloxycarbonyl)glycine

: 192655-69-9
dimethyl (S)-2-(benzylamino)pentanedioate

: 433285-17-7
dimethyl (S)-2-{N-benzyl-N-[2-(benzyloxycarbonylamino)acetyl]amino}pentanedioate

Guidance literature:: With dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane; at 20 ℃; for 16h;
DOI:10.1016/S0040-4020(01)01212-1

Reference yield:

: 56-86-0,21675-62-7,23009-64-5,25104-13-6,84960-48-5,25513-46-6
L-glutamic acid

: 433285-17-7
dimethyl (S)-2-{N-benzyl-N-[2-(benzyloxycarbonylamino)acetyl]amino}pentanedioate

Guidance literature:: Multi-step reaction with 4 steps

1: 100 percent / methanol / 16 h / 20 °C

2: 91 percent / triethylamine; Na₂SO₄ / pentane / 16 h / 20 °C

3: 93 percent / NaBH₄ / methanol / 0.5 h / 0 °C

4: 47 percent / DCC / tetrahydrofuran; CH₂Cl₂ / 16 h / 20 °C

With sodium tetrahydroborate; sodium sulfate; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; methanol; dichloromethane; pentane;
DOI:10.1016/S0040-4020(01)01212-1

Reference yield:

: 23150-65-4
L-glutamic dimethyl ester hydrochloride

: 433285-17-7
dimethyl (S)-2-{N-benzyl-N-[2-(benzyloxycarbonylamino)acetyl]amino}pentanedioate

Guidance literature:: Multi-step reaction with 3 steps

1: 91 percent / triethylamine; Na₂SO₄ / pentane / 16 h / 20 °C

2: 93 percent / NaBH₄ / methanol / 0.5 h / 0 °C

3: 47 percent / DCC / tetrahydrofuran; CH₂Cl₂ / 16 h / 20 °C

With sodium tetrahydroborate; sodium sulfate; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; methanol; dichloromethane; pentane;
DOI:10.1016/S0040-4020(01)01212-1