octahydro-pyrrolo[3,2-b]pyrrole-1,3,4-tricarboxylic acid 1-benzyl ester 4-tert-butyl ester

Base Information

Chemical Name:octahydro-pyrrolo[3,2-b]pyrrole-1,3,4-tricarboxylic acid 1-benzyl ester 4-tert-butyl ester
CAS No.:1257313-48-6
Molecular Formula:C₂₀H₂₆N₂O₆
Molecular Weight:390.436
Hs Code.:

Synonyms:octahydro-pyrrolo[3,2-b]pyrrole-1,3,4-tricarboxylic acid 1-benzyl ester 4-tert-butyl ester

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Chemical Property of octahydro-pyrrolo[3,2-b]pyrrole-1,3,4-tricarboxylic acid 1-benzyl ester 4-tert-butyl ester

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Technology Process of octahydro-pyrrolo[3,2-b]pyrrole-1,3,4-tricarboxylic acid 1-benzyl ester 4-tert-butyl ester

There total 1 articles about octahydro-pyrrolo[3,2-b]pyrrole-1,3,4-tricarboxylic acid 1-benzyl ester 4-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1257235-68-9
(3aR,6aR)-6R-(6-fluoro-1H-indol-3-yl)-octahydro-pyrrolo[3,2-b]pyrrole-1,3,4-tricarboxylic acid 1-benzyl ester 4-tert-butyl ester

: 1257313-48-6
octahydro-pyrrolo[3,2-b]pyrrole-1,3,4-tricarboxylic acid 1-benzyl ester 4-tert-butyl ester

Guidance literature:: With sodium periodate; ruthenium(III) trichloride hydrate; In tetrachloromethane; water; acetonitrile; for 3.83333h;

Reference yield:

: 186581-53-3,908094-01-9,334-88-3
diazomethane

: 1257313-48-6
octahydro-pyrrolo[3,2-b]pyrrole-1,3,4-tricarboxylic acid 1-benzyl ester 4-tert-butyl ester

: 1257235-70-3
hexahydro-pyrrolo[3,2-b]pyrrole-1,3,4-tricarboxylic acid 1-benzyl ester 4-tert-butyl ester 3-methyl ester

Guidance literature:: In diethyl ether;

Reference yield:

: 1257313-48-6
octahydro-pyrrolo[3,2-b]pyrrole-1,3,4-tricarboxylic acid 1-benzyl ester 4-tert-butyl ester

: 1257235-90-7
(1-{1-[6-(3,4-difluoro-phenoxymethyl)-hexahydro-pyrrolo[3,2-b]pyrrole-1-carbonyl]-2,2-dimethyl-propylcarbamoyl}-ethyl)-methyl-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 10 steps

1: diethyl ether

2: sodium methylate / methanol / 20 °C

3: diethyl ether

4: lithium borohydride / tetrahydrofuran / 0 °C

5: di-isopropyl azodicarboxylate; triphenylphosphine / benzene / 20 °C

6: trifluoroacetic acid / dichloromethane / 0 °C

7: N-ethyl-N,N-diisopropylamine; HATU / 1-methyl-pyrrolidin-2-one / 0 - 20 °C

8: trifluoroacetic acid / dichloromethane / 0 - 20 °C

9: N-ethyl-N,N-diisopropylamine; HATU / 1-methyl-pyrrolidin-2-one / 0 - 20 °C

10: hydrogen / palladium 10% on activated carbon / methanol / 2.5 h / 2585.81 Torr

With lithium borohydride; di-isopropyl azodicarboxylate; hydrogen; sodium methylate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; HATU; trifluoroacetic acid; palladium 10% on activated carbon; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; diethyl ether; dichloromethane; benzene;