2-(4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-3,5-difluorophenoxy)ethyl methanesulfonate

Base Information

Chemical Name:2-(4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-3,5-difluorophenoxy)ethyl methanesulfonate
CAS No.:1239963-57-5
Molecular Formula:C₂₉H₂₈ClF₃N₂O₅S₂
Molecular Weight:641.132
Hs Code.:

Synonyms:2-(4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-3,5-difluorophenoxy)ethyl methanesulfonate

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Chemical Property of 2-(4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-3,5-difluorophenoxy)ethyl methanesulfonate

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Technology Process of 2-(4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-3,5-difluorophenoxy)ethyl methanesulfonate

There total 16 articles about 2-(4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-3,5-difluorophenoxy)ethyl methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1239957-08-4
2-(4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-3,5-difluorophenoxy)ethanol

: 124-63-0
methanesulfonyl chloride

: 1239963-57-5
2-(4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-3,5-difluorophenoxy)ethyl methanesulfonate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; for 0.5h;

Reference yield:

: 850564-15-7
2-(4-Chloro-3-methoxy-phenyl)-2-methyl-propionitrile

: 1239963-57-5
2-(4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-3,5-difluorophenoxy)ethyl methanesulfonate

Guidance literature:: Multi-step reaction with 11 steps

1: sulfuric acid / 20 h / Reflux

2: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 3 h

3: tetrahydrofuran / 2 h / -78 - 20 °C

4: tetra-n-butylammonium tribromide / dichloromethane; methanol / 3 h / 0 - 20 °C

5: sodium azide / N,N-dimethyl-formamide / 2 h / 0 - 20 °C

6: hydrogenchloride; hydrogen / platinum(IV) oxide / methanol / 5 h / 3361.55 Torr

7: triethylamine / dichloromethane / 1 h / 0 - 20 °C

8: acetic acid / 4 h / Reflux

9: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 16 h

10: tetrabutyl ammonium fluoride / dichloromethane; tetrahydrofuran / 16 h

11: diisopropylamine / dichloromethane / 0.75 h / 20 °C

With hydrogenchloride; dmap; sodium azide; tetra-n-butylammonium tribromide; di-isopropyl azodicarboxylate; sulfuric acid; tetrabutyl ammonium fluoride; hydrogen; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; diisopropylamine; triphenylphosphine; platinum(IV) oxide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1239963-79-1
2-(4-chloro-3-methoxyphenyl)-N-methoxy-N,2-dimethylpropanamide

: 1239963-57-5
2-(4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-3,5-difluorophenoxy)ethyl methanesulfonate

Guidance literature:: Multi-step reaction with 9 steps

1: tetrahydrofuran / 2 h / -78 - 20 °C

2: tetra-n-butylammonium tribromide / dichloromethane; methanol / 3 h / 0 - 20 °C

3: sodium azide / N,N-dimethyl-formamide / 2 h / 0 - 20 °C

4: hydrogenchloride; hydrogen / platinum(IV) oxide / methanol / 5 h / 3361.55 Torr

5: triethylamine / dichloromethane / 1 h / 0 - 20 °C

6: acetic acid / 4 h / Reflux

7: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 16 h

8: tetrabutyl ammonium fluoride / dichloromethane; tetrahydrofuran / 16 h

9: diisopropylamine / dichloromethane / 0.75 h / 20 °C

With hydrogenchloride; sodium azide; tetra-n-butylammonium tribromide; di-isopropyl azodicarboxylate; tetrabutyl ammonium fluoride; hydrogen; acetic acid; triethylamine; diisopropylamine; triphenylphosphine; platinum(IV) oxide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;