cyano-4-[(ethylsulfanylthiocarbonyl)sulfanyl]-4-methylbutanoic acid

Base Information

• Chemical Name: cyano-4-[(ethylsulfanylthiocarbonyl)sulfanyl]-4-methylbutanoic acid
• CAS No.: 1137725-46-2
• Molecular Formula: C₉H₁₃NO₂S₃
• Molecular Weight: 263.406
• Hs Code.: 2930909899
• Mol file: 1137725-46-2.mol

Synonyms:cyano-4-[(ethylsulfanylthiocarbonyl)sulfanyl]-4-methylbutanoic acid

Chemical Property of cyano-4-[(ethylsulfanylthiocarbonyl)sulfanyl]-4-methylbutanoic acid

Chemical Property:

• Boiling Point: 490.7±45.0 °C(Predicted)
• Density: 1.329±0.06 g/cm3(Predicted)

Purity/Quality:

98% ^*data from raw suppliers

CETP ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of cyano-4-[(ethylsulfanylthiocarbonyl)sulfanyl]-4-methylbutanoic acid

There total 1 articles about cyano-4-[(ethylsulfanylthiocarbonyl)sulfanyl]-4-methylbutanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

bis(ethylsulfanylthiocarbonyl) disulfide (10219-97-3) + 4,4'-dicyano-4,4'-azo-di-valeric acid (2638-94-0,30248-30-7) → cyano-4-[(ethylsulfanylthiocarbonyl)sulfanyl]-4-methylbutanoic acid (1137725-46-2)

Guidance literature:

In ethyl acetate; Reflux; Inert atmosphere;

DOI:10.1021/jacs.7b10199

Reference yield: 91.8%

cyano-4-[(ethylsulfanylthiocarbonyl)sulfanyl]-4-methylbutanoic acid (1137725-46-2) + 4-(6-hydroxyhexyl-1-oxy)benzaldehyde (96735-91-0) → 6-(4-Formylphenoxy)hexyl 4-cyano-4-(((ethylthio)carbonothioyl) thio)pentanoate

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 25 ℃; for 4h; Inert atmosphere;

DOI:10.1039/c5ra04953a

Reference yield: 79.0%

1-hydroxy-pyrrolidine-2,5-dione (6066-82-6) + cyano-4-[(ethylsulfanylthiocarbonyl)sulfanyl]-4-methylbutanoic acid (1137725-46-2) → 2,5-dioxopyrrolidin-1-yl 4-cyano-4-(((ethylthio)carbonothioyl)thio)pentanoate (1195771-65-3)

Guidance literature:

With dicyclohexyl-carbodiimide; In chloroform; at 0 - 20 ℃; for 23h;

DOI:10.1016/j.tetlet.2018.12.051

upstream raw materials:

bis(ethylsulfanylthiocarbonyl) disulfide

4,4'-dicyano-4,4'-azo-di-valeric acid

Downstream raw materials:

2,5-dioxopyrrolidin-1-yl 4-cyano-4-(((ethylthio)carbonothioyl)thio)pentanoate

Refernces

• 1、 Li, Hongmei,Yu, Shann S.,Miteva, Martina,Nelson, Christopher E.,Werfel, Thomas,Giorgio, Todd D.,Duvall, Craig L.. "Matrix metalloproteinase responsive, proximity-activated polymeric nanoparticles for siRNA delivery". . p. 3040 - 3052. Retrieved 2013.
• 2、 Arno, Maria C.,Inam, Maria,Coe, Zachary,Cambridge, Graeme,Macdougall, Laura J.,Keogh, Robert,Dove, Andrew P.,O'Reilly, Rachel K.. "Precision Epitaxy for Aqueous 1D and 2D Poly(? -caprolactone) Assemblies". . p. 16980 - 16985. Retrieved 2017.
• 3、 Johnson, Russell N.,Burke, Rob S.,Convertine, Anthony J.,Hoffman, Allan S.,Stayton, Patrick S.,Pun, Suzie H.. "Synthesis of statistical copolymers containing multiple functional peptides for nucleic acid delivery". . p. 3007 - 3013. Retrieved 2010.
• 4、 -. "Preparation method of RAFT chain transfer agent with good water solubility". Paragraph 0046; 0049; 0051; 0054; 0056; 0059; 0061; 0064. . Retrieved 2020/04/29.