(2S,4S)-1-(tert-butoxycarbonyl)-2-hydroxymethyl-4-phenylaminopyrrolidine

Base Information

Chemical Name:(2S,4S)-1-(tert-butoxycarbonyl)-2-hydroxymethyl-4-phenylaminopyrrolidine
CAS No.:1350477-13-2
Molecular Formula:C₁₆H₂₄N₂O₃
Molecular Weight:292.378
Hs Code.:

Synonyms:(2S,4S)-1-(tert-butoxycarbonyl)-2-hydroxymethyl-4-phenylaminopyrrolidine

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Chemical Property of (2S,4S)-1-(tert-butoxycarbonyl)-2-hydroxymethyl-4-phenylaminopyrrolidine

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Technology Process of (2S,4S)-1-(tert-butoxycarbonyl)-2-hydroxymethyl-4-phenylaminopyrrolidine

There total 3 articles about (2S,4S)-1-(tert-butoxycarbonyl)-2-hydroxymethyl-4-phenylaminopyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1350477-09-6
(2S,4S)-1-(tert-butoxycarbonyl)-5-oxo-4-phenylaminoproline methyl ester

: 1350477-15-4
2-(tert-butoxycarbonyl)-5-phenyl-2,5-diazabicyclo[2.2.1]heptane

: 1350477-13-2
(2S,4S)-1-(tert-butoxycarbonyl)-2-hydroxymethyl-4-phenylaminopyrrolidine

Guidance literature:: With borane dimethyl sulphide complex; In tetrahydrofuran; at 40 ℃; for 96h; Inert atmosphere;
DOI:10.1007/s11172-011-0137-4

Reference yield:

: 1032764-56-9
methyl (2S,4S)-5-oxo-4-phenylaminoprolinate

: 1350477-15-4
2-(tert-butoxycarbonyl)-5-phenyl-2,5-diazabicyclo[2.2.1]heptane

: 1350477-13-2
(2S,4S)-1-(tert-butoxycarbonyl)-2-hydroxymethyl-4-phenylaminopyrrolidine

Guidance literature:: Multi-step reaction with 2 steps

1: dmap; triethylamine / dichloromethane / 2 h / 20 °C

2: borane dimethyl sulphide complex / tetrahydrofuran / 96 h / 40 °C / Inert atmosphere

With dmap; borane dimethyl sulphide complex; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1007/s11172-011-0137-4

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1350477-15-4
2-(tert-butoxycarbonyl)-5-phenyl-2,5-diazabicyclo[2.2.1]heptane

: 1350477-13-2
(2S,4S)-1-(tert-butoxycarbonyl)-2-hydroxymethyl-4-phenylaminopyrrolidine

Guidance literature:: Multi-step reaction with 2 steps

1: dmap; triethylamine / dichloromethane / 2 h / 20 °C

2: borane dimethyl sulphide complex / tetrahydrofuran / 96 h / 40 °C / Inert atmosphere

With dmap; borane dimethyl sulphide complex; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1007/s11172-011-0137-4