ethyl 7-[(methylsulfonyl)amino]-4-oxo-6-phenoxy-4H-3-chromenecarboxylate

Base Information

Chemical Name:ethyl 7-[(methylsulfonyl)amino]-4-oxo-6-phenoxy-4H-3-chromenecarboxylate
CAS No.:123663-68-3
Molecular Formula:C₁₉H₁₇NO₇S
Molecular Weight:403.412
Hs Code.:

Synonyms:ethyl 7-[(methylsulfonyl)amino]-4-oxo-6-phenoxy-4H-3-chromenecarboxylate

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Chemical Property of ethyl 7-[(methylsulfonyl)amino]-4-oxo-6-phenoxy-4H-3-chromenecarboxylate

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Technology Process of ethyl 7-[(methylsulfonyl)amino]-4-oxo-6-phenoxy-4H-3-chromenecarboxylate

There total 10 articles about ethyl 7-[(methylsulfonyl)amino]-4-oxo-6-phenoxy-4H-3-chromenecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 4637-24-5
N,N-dimethyl-formamide dimethyl acetal

: 123664-56-2
ethyl 3-[2-hydroxy-4-[(methylsulfonyl)amino]-5-phenoxyphenyl]-3-oxopropanoate

: 123663-68-3
ethyl 7-[(methylsulfonyl)amino]-4-oxo-6-phenoxy-4H-3-chromenecarboxylate

Guidance literature:: In N,N-dimethyl-formamide; at 20 ℃; for 1h;
DOI:10.1248/cpb.48.131

Reference yield: 88.1%

: 123663-68-3
ethyl 7-[(methylsulfonyl)amino]-4-oxo-6-phenoxy-4H-3-chromenecarboxylate

Guidance literature:

Reference yield:

: 84594-95-6
5-methoxy-1-nitro-2-phenoxybenzene

: 123663-68-3
ethyl 7-[(methylsulfonyl)amino]-4-oxo-6-phenoxy-4H-3-chromenecarboxylate

Guidance literature:: Multi-step reaction with 7 steps

1: 72 percent / 4N aq. HCl; Fe / ethanol / 0.33 h / 65 - 70 °C

2: 82 percent / pyridine / 1 h / 20 °C

3: 84 percent / aluminum chloride / CH₂Cl₂ / 1 h / 15 - 20 °C

4: 50 percent / NaH / dimethylformamide

5: 66 percent / NaH / dimethylformamide / 0.5 h / 90 - 100 °C

6: 90 percent / H₂ / 5 percent Pd/C / ethanol

7: 89 percent / dimethylformamide / 1 h / 20 °C

With pyridine; hydrogenchloride; aluminium trichloride; hydrogen; iron; sodium hydride; palladium on activated charcoal; In ethanol; dichloromethane; N,N-dimethyl-formamide; 1: Reduction / 2: Mesylation / 3: Acetylation / 4: Alkylation / 5: ethoxycarbonylation / 6: catalytic hydrogenolysis / 7: Cyclization;
DOI:10.1248/cpb.48.131