4-ethyl 3-isopropyl 5-acetyl-1-(4-methoxyphenyl)-2,6-dimethyl-1,4-dihydropyridine-3,4-dicarboxylate

Base Information

• Chemical Name: 4-ethyl 3-isopropyl 5-acetyl-1-(4-methoxyphenyl)-2,6-dimethyl-1,4-dihydropyridine-3,4-dicarboxylate
• CAS No.: 1437798-92-9
• Molecular Formula: C₂₃H₂₉NO₆
• Molecular Weight: 415.486
• Mol file: 1437798-92-9.mol

Synonyms:4-ethyl 3-isopropyl 5-acetyl-1-(4-methoxyphenyl)-2,6-dimethyl-1,4-dihydropyridine-3,4-dicarboxylate

Chemical Property of 4-ethyl 3-isopropyl 5-acetyl-1-(4-methoxyphenyl)-2,6-dimethyl-1,4-dihydropyridine-3,4-dicarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-ethyl 3-isopropyl 5-acetyl-1-(4-methoxyphenyl)-2,6-dimethyl-1,4-dihydropyridine-3,4-dicarboxylate

There total 4 articles about 4-ethyl 3-isopropyl 5-acetyl-1-(4-methoxyphenyl)-2,6-dimethyl-1,4-dihydropyridine-3,4-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

isopropyl acetoacetate (542-08-5) + N-(4-methoxy)phenylglycine ethyl ester (50845-77-7) + acetylacetone (123-54-6,81235-32-7) → 4-ethyl 3-isopropyl 5-acetyl-1-(4-methoxyphenyl)-2,6-dimethyl-1,4-dihydropyridine-3,4-dicarboxylate (1437798-92-9)

Guidance literature:

With oxygen; copper(II) bis(trifluoromethanesulfonate); In toluene; at 60 ℃; for 12h; under 760.051 Torr; Green chemistry;

DOI:10.1021/acs.joc.6b01736

Reference yield:

glyoxylic acid ethyl ester (924-44-7) + isopropyl acetoacetate (542-08-5) + 4-(4-methoxyphenyl)imino-3-pentene-2-one (20010-38-2) → 4-ethyl 3-isopropyl 5-acetyl-1-(4-methoxyphenyl)-2,6-dimethyl-1,4-dihydropyridine-3,4-dicarboxylate (1437798-92-9)

Guidance literature:

at 20 ℃;

DOI:10.1016/j.tet.2013.04.006

Reference yield:

acetylacetone (123-54-6,81235-32-7) → 4-ethyl 3-isopropyl 5-acetyl-1-(4-methoxyphenyl)-2,6-dimethyl-1,4-dihydropyridine-3,4-dicarboxylate (1437798-92-9)

Guidance literature:

Multi-step reaction with 2 steps

1: montmorillonite K-10 / 6 h / 20 °C / Green chemistry

2: 20 °C

With montmorillonite K-10;

DOI:10.1016/j.tet.2013.04.006

upstream raw materials:

glyoxylic acid ethyl ester

isopropyl acetoacetate

4-(4-methoxyphenyl)imino-3-pentene-2-one

acetylacetone