4-(2-((tert-butyldimethylsilyl)oxy)ethoxy)-3-(difluoromethoxy)aniline

Base Information

Chemical Name:4-(2-((tert-butyldimethylsilyl)oxy)ethoxy)-3-(difluoromethoxy)aniline
CAS No.:1574541-95-9
Molecular Formula:C₁₅H₂₅F₂NO₃Si
Molecular Weight:333.451
Hs Code.:

Synonyms:4-(2-((tert-butyldimethylsilyl)oxy)ethoxy)-3-(difluoromethoxy)aniline

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-(2-((tert-butyldimethylsilyl)oxy)ethoxy)-3-(difluoromethoxy)aniline

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Technology Process of 4-(2-((tert-butyldimethylsilyl)oxy)ethoxy)-3-(difluoromethoxy)aniline

There total 4 articles about 4-(2-((tert-butyldimethylsilyl)oxy)ethoxy)-3-(difluoromethoxy)aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.7%

: 1574541-94-8
tert-butyl(2-(2-(difluoromethoxy)-4-nitrophenoxy)ethoxy)dimethylsilane

: 1574541-95-9
4-(2-((tert-butyldimethylsilyl)oxy)ethoxy)-3-(difluoromethoxy)aniline

Guidance literature:: With 5%-palladium/activated carbon; ammonium formate; In ethanol; for 0.333333h;

Reference yield:

: 2620-44-2
5-nitro-1,3-benzodioxole

: 1574541-95-9
4-(2-((tert-butyldimethylsilyl)oxy)ethoxy)-3-(difluoromethoxy)aniline

Guidance literature:: Multi-step reaction with 4 steps

1: sodium / 3 h / 120 °C

2: potassium carbonate / N,N-dimethyl-formamide / 2 h / 80 °C

3: 1H-imidazole / dichloromethane / 1.17 h / 0 - 20 °C

4: 5%-palladium/activated carbon; ammonium formate / ethanol / 0.33 h

With 1H-imidazole; 5%-palladium/activated carbon; ammonium formate; sodium; potassium carbonate; In ethanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 2-(2-hydroxyethoxy)-5-nitrophenol

: 1574541-95-9
4-(2-((tert-butyldimethylsilyl)oxy)ethoxy)-3-(difluoromethoxy)aniline

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 80 °C

2: 1H-imidazole / dichloromethane / 1.17 h / 0 - 20 °C

3: 5%-palladium/activated carbon; ammonium formate / ethanol / 0.33 h

With 1H-imidazole; 5%-palladium/activated carbon; ammonium formate; potassium carbonate; In ethanol; dichloromethane; N,N-dimethyl-formamide;