4-Piperidineaceticacid,5-ethyl-2-oxo-,ethylester,(4R,5S)-(9CI)

Base Information

Chemical Name:4-Piperidineaceticacid,5-ethyl-2-oxo-,ethylester,(4R,5S)-(9CI)
CAS No.:457623-01-7
Molecular Formula:C₁₁H₁₉NO₃
Molecular Weight:213.277
Hs Code.:
Mol file:457623-01-7.mol

Synonyms:4-Piperidineaceticacid,5-ethyl-2-oxo-,ethylester,(4R,5S)-(9CI)

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-Piperidineaceticacid,5-ethyl-2-oxo-,ethylester,(4R,5S)-(9CI)

Chemical Property:

PSA：58.89000
LogP:1.37780

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 4-Piperidineaceticacid,5-ethyl-2-oxo-,ethylester,(4R,5S)-(9CI)

There total 6 articles about 4-Piperidineaceticacid,5-ethyl-2-oxo-,ethylester,(4R,5S)-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 457622-98-9
((3R,7R,8S,8aR)-8-Ethyl-5-oxo-3-phenyl-hexahydro-oxazolo[3,2-a]pyridin-7-yl)-acetic acid ethyl ester

: 457623-01-7
-essigsaeure-ethylester

Guidance literature:: ((3R,7R,8S,8aR)-8-Ethyl-5-oxo-3-phenyl-hexahydro-oxazolo[3,2-a]pyridin-7-yl)-acetic acid ethyl ester; With ammonia; calcium;

With triethylsilane; trifluoroacetic acid; Further stages.;
DOI:10.1021/ol0263245

Reference yield:

: 331473-26-8
8-ethyl-5-oxo-3-phenyl-2,3,8,8a-tetrahydro-5H-oxazolo[3,2-a]pyridine-6-carboxylic acid benzyl ester

: 457623-01-7
-essigsaeure-ethylester

Guidance literature:: Multi-step reaction with 6 steps

1.1: 86 percent / phenyllithium; copper(I) iodide; trimethylsilyl chloride / lithium chloride / tetrahydrofuran

2.1: ozone / CH₂Cl₂; methanol

2.2: dimethyl sulfide / CH₂Cl₂; methanol

3.1: pyridinium dichromate / dimethylformamide

4.1: trimethylsilyl chloride

5.1: hydrogen / 10percent Pd/C

5.2: 82 percent / toluene / Heating

6.1: calcium; liq. NH₃

6.2: 35 percent / triethylsilane; trifluoroacetic acid

With copper(l) iodide; dipyridinium dichromate; chloro-trimethyl-silane; ammonia; hydrogen; calcium; ozone; phenyllithium; lithium chloride; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ol0263245

Reference yield:

: (3R,7R,8S,8aR)-8-Ethyl-5-oxo-7-(2-oxo-ethyl)-3-phenyl-hexahydro-oxazolo[3,2-a]pyridine-6-carboxylic acid benzyl ester

: 457623-01-7
-essigsaeure-ethylester

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyridinium dichromate / dimethylformamide

2.1: trimethylsilyl chloride

3.1: hydrogen / 10percent Pd/C

3.2: 82 percent / toluene / Heating

4.1: calcium; liq. NH₃

4.2: 35 percent / triethylsilane; trifluoroacetic acid

With dipyridinium dichromate; chloro-trimethyl-silane; ammonia; hydrogen; calcium; 10percent Pd/C; In N,N-dimethyl-formamide;
DOI:10.1021/ol0263245