[tert-butoxycarbonyl-(2-{2-[(5-carbamimidoyl-1-methyl-1H-pyrrol-2-ylmethyl)-carbamoyl]-2,5-dihydro-pyrrol-1-yl}-1-cyclohexylmethyl-2-oxo-ethyl)-amino]-acetic acid tert-butyl ester

Base Information

Chemical Name:[tert-butoxycarbonyl-(2-{2-[(5-carbamimidoyl-1-methyl-1H-pyrrol-2-ylmethyl)-carbamoyl]-2,5-dihydro-pyrrol-1-yl}-1-cyclohexylmethyl-2-oxo-ethyl)-amino]-acetic acid tert-butyl ester
CAS No.:203792-91-0
Molecular Formula:C₃₂H₅₀N₆O₆
Molecular Weight:614.786
Hs Code.:

[<i>tert</i>-butoxycarbonyl-(2-{2-[(5-carbamimidoyl-1-methyl-1<i>H</i>-pyrrol-2-ylmethyl)-carbamoyl]-2,5-dihydro-pyrrol-1-yl}-1-cyclohexylmethyl-2-oxo-ethyl)-amino]-acetic acid <i>tert</i>-butyl ester

Synonyms:[tert-butoxycarbonyl-(2-{2-[(5-carbamimidoyl-1-methyl-1H-pyrrol-2-ylmethyl)-carbamoyl]-2,5-dihydro-pyrrol-1-yl}-1-cyclohexylmethyl-2-oxo-ethyl)-amino]-acetic acid tert-butyl ester

Suppliers and Price of [tert-butoxycarbonyl-(2-{2-[(5-carbamimidoyl-1-methyl-1H-pyrrol-2-ylmethyl)-carbamoyl]-2,5-dihydro-pyrrol-1-yl}-1-cyclohexylmethyl-2-oxo-ethyl)-amino]-acetic acid tert-butyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of [tert-butoxycarbonyl-(2-{2-[(5-carbamimidoyl-1-methyl-1H-pyrrol-2-ylmethyl)-carbamoyl]-2,5-dihydro-pyrrol-1-yl}-1-cyclohexylmethyl-2-oxo-ethyl)-amino]-acetic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of [tert-butoxycarbonyl-(2-{2-[(5-carbamimidoyl-1-methyl-1H-pyrrol-2-ylmethyl)-carbamoyl]-2,5-dihydro-pyrrol-1-yl}-1-cyclohexylmethyl-2-oxo-ethyl)-amino]-acetic acid tert-butyl ester

There total 13 articles about [tert-butoxycarbonyl-(2-{2-[(5-carbamimidoyl-1-methyl-1H-pyrrol-2-ylmethyl)-carbamoyl]-2,5-dihydro-pyrrol-1-yl}-1-cyclohexylmethyl-2-oxo-ethyl)-amino]-acetic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 203792-23-8
1-[2-(tert-butoxycarbonyl-tert-butoxycarbonylmethyl-amino)-3-cyclohexyl-propionyl]-2,5-dihydro-1H-pyrrole-2-carboxylic acid

: 758683-10-2
5-aminomethyl-1-methyl-1H-pyrrole-2-carboxamidine

: 203792-91-0
[tert-butoxycarbonyl-(2-{2-[(5-carbamimidoyl-1-methyl-1H-pyrrol-2-ylmethyl)-carbamoyl]-2,5-dihydro-pyrrol-1-yl}-1-cyclohexylmethyl-2-oxo-ethyl)-amino]-acetic acid tert-butyl ester

Guidance literature:: With 4-methyl-morpholine; O-[(ethoxycarbonyl)cyanomethyleneamino]-N,N,N',N'-tetramethyluronium tetrafluoroborate; In N,N-dimethyl-formamide; at 0 ℃; for 1h;
DOI:10.1016/j.bmcl.2006.02.040

Reference yield:

: 96-54-8
N-Methylpyrrole

: 203792-91-0
[tert-butoxycarbonyl-(2-{2-[(5-carbamimidoyl-1-methyl-1H-pyrrol-2-ylmethyl)-carbamoyl]-2,5-dihydro-pyrrol-1-yl}-1-cyclohexylmethyl-2-oxo-ethyl)-amino]-acetic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 11 steps

1: 61 percent / CSI / dimethylformamide / -78 - 20 °C

2: 54 percent / LDA

3: 91 percent / NaBH₄ / ethanol

4: CBr₄; PPh₃

5: NaN₃

6: 68 percent / H₂ / Pd/C / methanol

7: 94 percent / Et₃N / CH₂Cl₂

8: 69 percent / NH₂OH*HCl; DIEA / methanol; CH₂Cl₂

9: H₂; AcOH / Raney-Ni / methanol

10: HCl / CH₂Cl₂

11: NMM; TOTU / dimethylformamide / 0 °C

With 4-methyl-morpholine; hydrogenchloride; sodium tetrahydroborate; sodium azide; isocyanate de chlorosulfonyle; O-[(ethoxycarbonyl)cyanomethyleneamino]-N,N,N',N'-tetramethyluronium tetrafluoroborate; carbon tetrabromide; hydroxylamine hydrochloride; hydrogen; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; lithium diisopropyl amide; palladium on activated charcoal; nickel; In methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(03)00347-0

Reference yield:

: 34884-10-1
1-methyl-1H-pyrrole-2-carbonitrile

: 203792-91-0
[tert-butoxycarbonyl-(2-{2-[(5-carbamimidoyl-1-methyl-1H-pyrrol-2-ylmethyl)-carbamoyl]-2,5-dihydro-pyrrol-1-yl}-1-cyclohexylmethyl-2-oxo-ethyl)-amino]-acetic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 10 steps

1: 54 percent / LDA

2: 91 percent / NaBH₄ / ethanol

3: CBr₄; PPh₃

4: NaN₃

5: 68 percent / H₂ / Pd/C / methanol

6: 94 percent / Et₃N / CH₂Cl₂

7: 69 percent / NH₂OH*HCl; DIEA / methanol; CH₂Cl₂

8: H₂; AcOH / Raney-Ni / methanol

9: HCl / CH₂Cl₂

10: NMM; TOTU / dimethylformamide / 0 °C

With 4-methyl-morpholine; hydrogenchloride; sodium tetrahydroborate; sodium azide; O-[(ethoxycarbonyl)cyanomethyleneamino]-N,N,N',N'-tetramethyluronium tetrafluoroborate; carbon tetrabromide; hydroxylamine hydrochloride; hydrogen; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; lithium diisopropyl amide; palladium on activated charcoal; nickel; In methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(03)00347-0