{2-[(Z)-5-(tert-Butyl-diphenyl-silanyloxy)-7-iodo-hept-3-ene-1,6-diynyl]-phenyl}-methanol

Base Information

Chemical Name:{2-[(Z)-5-(tert-Butyl-diphenyl-silanyloxy)-7-iodo-hept-3-ene-1,6-diynyl]-phenyl}-methanol
CAS No.:207789-66-0
Molecular Formula:C₃₀H₂₉IO₂Si
Molecular Weight:576.549
Hs Code.:

Synonyms:{2-[(Z)-5-(tert-Butyl-diphenyl-silanyloxy)-7-iodo-hept-3-ene-1,6-diynyl]-phenyl}-methanol

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Chemical Property of {2-[(Z)-5-(tert-Butyl-diphenyl-silanyloxy)-7-iodo-hept-3-ene-1,6-diynyl]-phenyl}-methanol

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Technology Process of {2-[(Z)-5-(tert-Butyl-diphenyl-silanyloxy)-7-iodo-hept-3-ene-1,6-diynyl]-phenyl}-methanol

There total 8 articles about {2-[(Z)-5-(tert-Butyl-diphenyl-silanyloxy)-7-iodo-hept-3-ene-1,6-diynyl]-phenyl}-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 207789-65-9
{2-[(Z)-5-(tert-Butyl-diphenyl-silanyloxy)-hept-3-ene-1,6-diynyl]-phenyl}-methanol

: 207789-66-0
{2-[(Z)-5-(tert-Butyl-diphenyl-silanyloxy)-7-iodo-hept-3-ene-1,6-diynyl]-phenyl}-methanol

Guidance literature:: With morpholine; iodine; In tetrahydrofuran; at 50 ℃; for 5h;
DOI:10.1055/s-1998-1693

Reference yield:

: 10602-08-1
2-ethynylbenzyl alcohol

: 207789-66-0
{2-[(Z)-5-(tert-Butyl-diphenyl-silanyloxy)-7-iodo-hept-3-ene-1,6-diynyl]-phenyl}-methanol

Guidance literature:: Multi-step reaction with 3 steps

1: 95 percent / i-Pr₂NH / Pd(PPh₃)2Cl₂, CuI / tetrahydrofuran / 2 h / Ambient temperature

2: 95 percent / K₂CO₃ / methanol / 4 h / Ambient temperature

3: 94 percent / I₂, morpholine / tetrahydrofuran / 5 h / 50 °C

With morpholine; iodine; potassium carbonate; diisopropylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In tetrahydrofuran; methanol;
DOI:10.1055/s-1998-1693

Reference yield:

: 77123-58-1
2-[2-(trimethylsilyl)ethynyl]benzaldehyde

: 207789-66-0
{2-[(Z)-5-(tert-Butyl-diphenyl-silanyloxy)-7-iodo-hept-3-ene-1,6-diynyl]-phenyl}-methanol

Guidance literature:: Multi-step reaction with 5 steps

1: NaBH₄ / ethanol / 0.33 h / 0 °C

2: H₂O, NH₄F, n-Bu₄NHSO₄ / CH₂Cl₂ / 1 h / Ambient temperature

3: 95 percent / i-Pr₂NH / Pd(PPh₃)2Cl₂, CuI / tetrahydrofuran / 2 h / Ambient temperature

4: 95 percent / K₂CO₃ / methanol / 4 h / Ambient temperature

5: 94 percent / I₂, morpholine / tetrahydrofuran / 5 h / 50 °C

With morpholine; ammonium fluoride; sodium tetrahydroborate; water; iodine; tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate; diisopropylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In tetrahydrofuran; methanol; ethanol; dichloromethane;
DOI:10.1055/s-1998-1693