cyclopropanecarboxylic acid (3-(4-(3-(6-amino-5-trifluoromethylpyridin-3-yl)imidazo[1,2-b]pyridazin-6-yl)phenoxymethyl)oxetan-3-yl)amide

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Chemical Name:cyclopropanecarboxylic acid (3-(4-(3-(6-amino-5-trifluoromethylpyridin-3-yl)imidazo[1,2-b]pyridazin-6-yl)phenoxymethyl)oxetan-3-yl)amide
CAS No.:1084952-60-2
Molecular Formula:C₂₆H₂₃F₃N₆O₃
Molecular Weight:524.502
Hs Code.:

Synonyms:cyclopropanecarboxylic acid (3-(4-(3-(6-amino-5-trifluoromethylpyridin-3-yl)imidazo[1,2-b]pyridazin-6-yl)phenoxymethyl)oxetan-3-yl)amide

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Chemical Property of cyclopropanecarboxylic acid (3-(4-(3-(6-amino-5-trifluoromethylpyridin-3-yl)imidazo[1,2-b]pyridazin-6-yl)phenoxymethyl)oxetan-3-yl)amide

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Technology Process of cyclopropanecarboxylic acid (3-(4-(3-(6-amino-5-trifluoromethylpyridin-3-yl)imidazo[1,2-b]pyridazin-6-yl)phenoxymethyl)oxetan-3-yl)amide

There total 6 articles about cyclopropanecarboxylic acid (3-(4-(3-(6-amino-5-trifluoromethylpyridin-3-yl)imidazo[1,2-b]pyridazin-6-yl)phenoxymethyl)oxetan-3-yl)amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1084952-61-3
5-(6-(4-(3-aminooxetan-3-ylmethoxy)phenyl)imidazo[1,2-b]pyridazin-3-yl)-3-trifluoromethylpyridin-2-ylamine

: 4023-34-1
cyclopropanecarboxylic acid chloride

: 1084952-60-2
cyclopropanecarboxylic acid (3-(4-(3-(6-amino-5-trifluoromethylpyridin-3-yl)imidazo[1,2-b]pyridazin-6-yl)phenoxymethyl)oxetan-3-yl)amide

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 3h;

Reference yield:

: 1083430-01-6
[3-(4-bromo-phenoxymethyl)oxetan-3-yl]methanol

: 1084952-60-2
cyclopropanecarboxylic acid (3-(4-(3-(6-amino-5-trifluoromethylpyridin-3-yl)imidazo[1,2-b]pyridazin-6-yl)phenoxymethyl)oxetan-3-yl)amide

Guidance literature:: Multi-step reaction with 6 steps

1: sodium chlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / acetonitrile / 20 h / 20 - 77 °C / pH 7 / Aqueous phosphate buffer

2: diphenyl phosphoryl azide; triethylamine / toluene / 5 h / 100 °C

3: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / toluene / 16 h / Heating / reflux

4: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / ethanol; toluene / 16 h / Heating / reflux

5: hydrogen / palladium 10% on activated carbon / tetrahydrofuran / 8 h / 20 °C / 3750.38 Torr

6: triethylamine / dichloromethane / 3 h / 20 °C

With sodium chlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; diphenyl phosphoryl azide; hydrogen; potassium acetate; potassium carbonate; triethylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane; toluene; acetonitrile;

Reference yield:

: 1083429-99-5
benzyl N-[3-[(4-bromophenoxy)methyl]oxetan-3-yl]carbamate

: 1084952-60-2
cyclopropanecarboxylic acid (3-(4-(3-(6-amino-5-trifluoromethylpyridin-3-yl)imidazo[1,2-b]pyridazin-6-yl)phenoxymethyl)oxetan-3-yl)amide

Guidance literature:: Multi-step reaction with 4 steps

1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / toluene / 16 h / Heating / reflux

2: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / ethanol; toluene / 16 h / Heating / reflux

3: hydrogen / palladium 10% on activated carbon / tetrahydrofuran / 8 h / 20 °C / 3750.38 Torr

4: triethylamine / dichloromethane / 3 h / 20 °C

With hydrogen; potassium acetate; potassium carbonate; triethylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane; toluene;