5-(6-(4-(3-aminooxetan-3-ylmethoxy)phenyl)imidazo[1,2-b]pyridazin-3-yl)-3-trifluoromethylpyridin-2-ylamine

Base Information

Chemical Name:5-(6-(4-(3-aminooxetan-3-ylmethoxy)phenyl)imidazo[1,2-b]pyridazin-3-yl)-3-trifluoromethylpyridin-2-ylamine
CAS No.:1084952-61-3
Molecular Formula:C₂₂H₁₉F₃N₆O₂
Molecular Weight:456.427
Hs Code.:

Synonyms:5-(6-(4-(3-aminooxetan-3-ylmethoxy)phenyl)imidazo[1,2-b]pyridazin-3-yl)-3-trifluoromethylpyridin-2-ylamine

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Chemical Property of 5-(6-(4-(3-aminooxetan-3-ylmethoxy)phenyl)imidazo[1,2-b]pyridazin-3-yl)-3-trifluoromethylpyridin-2-ylamine

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Technology Process of 5-(6-(4-(3-aminooxetan-3-ylmethoxy)phenyl)imidazo[1,2-b]pyridazin-3-yl)-3-trifluoromethylpyridin-2-ylamine

There total 5 articles about 5-(6-(4-(3-aminooxetan-3-ylmethoxy)phenyl)imidazo[1,2-b]pyridazin-3-yl)-3-trifluoromethylpyridin-2-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1084953-20-7
(3-(4-(3-(6-amino-5-trifluoromethylpyridin-3-yl)imidazo[1,2-b]pyridazin-6-yl)phenoxymethyl)oxetan-3-yl)carbamic acid benzyl ester

: 1084952-61-3
5-(6-(4-(3-aminooxetan-3-ylmethoxy)phenyl)imidazo[1,2-b]pyridazin-3-yl)-3-trifluoromethylpyridin-2-ylamine

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In tetrahydrofuran; at 20 ℃; for 8h; under 3750.38 Torr;

Reference yield:

: 1083430-01-6
[3-(4-bromo-phenoxymethyl)oxetan-3-yl]methanol

: 1084952-61-3
5-(6-(4-(3-aminooxetan-3-ylmethoxy)phenyl)imidazo[1,2-b]pyridazin-3-yl)-3-trifluoromethylpyridin-2-ylamine

Guidance literature:: Multi-step reaction with 5 steps

1: sodium chlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / acetonitrile / 20 h / 20 - 77 °C / pH 7 / Aqueous phosphate buffer

2: diphenyl phosphoryl azide; triethylamine / toluene / 5 h / 100 °C

3: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / toluene / 16 h / Heating / reflux

4: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / ethanol; toluene / 16 h / Heating / reflux

5: hydrogen / palladium 10% on activated carbon / tetrahydrofuran / 8 h / 20 °C / 3750.38 Torr

With sodium chlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; diphenyl phosphoryl azide; hydrogen; potassium acetate; potassium carbonate; triethylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; toluene; acetonitrile;

Reference yield:

: 1083430-00-5
3-(4-bromo-phenoxymethyl)-oxetane-3-carboxylic acid

: 1084952-61-3
5-(6-(4-(3-aminooxetan-3-ylmethoxy)phenyl)imidazo[1,2-b]pyridazin-3-yl)-3-trifluoromethylpyridin-2-ylamine

Guidance literature:: Multi-step reaction with 4 steps

1: diphenyl phosphoryl azide; triethylamine / toluene / 5 h / 100 °C

2: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / toluene / 16 h / Heating / reflux

3: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / ethanol; toluene / 16 h / Heating / reflux

4: hydrogen / palladium 10% on activated carbon / tetrahydrofuran / 8 h / 20 °C / 3750.38 Torr

With diphenyl phosphoryl azide; hydrogen; potassium acetate; potassium carbonate; triethylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; toluene;