(4R,5R)-5-phenyl-4-(p-tolylsulfonyl)-4,5-dihydrooxazole

Base Information

Chemical Name:(4R,5R)-5-phenyl-4-(p-tolylsulfonyl)-4,5-dihydrooxazole
CAS No.:131101-43-4
Molecular Formula:C₁₆H₁₅NO₃S
Molecular Weight:301.366
Hs Code.:
ChEMBL ID:CHEMBL4649695
DSSTox Substance ID:DTXSID201172105
Nikkaji Number:J348.180H

Synonyms:131101-43-4;CHEMBL4649695;DTXSID201172105;(4R,5R)-5-phenyl-4-(p-tolylsulfonyl)-4,5-dihydrooxazole;(4R,5R)-4,5-Dihydro-4-[(4-methylphenyl)sulfonyl]-5-phenyloxazole

Suppliers and Price of (4R,5R)-5-phenyl-4-(p-tolylsulfonyl)-4,5-dihydrooxazole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of (4R,5R)-5-phenyl-4-(p-tolylsulfonyl)-4,5-dihydrooxazole

Chemical Property:

XLogP3:2.8
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:301.07726451
Heavy Atom Count:21
Complexity:468

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=CC=C(C=C1)S(=O)(=O)C2C(OC=N2)C3=CC=CC=C3
Isomeric SMILES:CC1=CC=C(C=C1)S(=O)(=O)[C@@H]2[C@H](OC=N2)C3=CC=CC=C3

Technology Process of (4R,5R)-5-phenyl-4-(p-tolylsulfonyl)-4,5-dihydrooxazole

There total 5 articles about (4R,5R)-5-phenyl-4-(p-tolylsulfonyl)-4,5-dihydrooxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 38622-91-2,36635-61-7
[(p-methylphenyl)sulfonylmethyl]isonitrile

: 100-52-7
benzaldehyde

: 40078-73-7,131101-43-4
(4R,5R)/(4S,5S)-5-phenyl-4-tosyl-4,5-dihydrooxazole

Guidance literature:: With triethylamine; In methanol; at 20 ℃; optical yield given as %de; diastereoselective reaction;
DOI:10.2174/157017809788489855

Reference yield: 93.0%

: 38622-91-2,36635-61-7
[(p-methylphenyl)sulfonylmethyl]isonitrile

: 100-51-6,185532-71-2
benzyl alcohol

: 40078-73-7,131101-43-4
C₁₆H₁₅NO₃S

Guidance literature:: With 2-aminopyridine; potassium hydroxide; In acetonitrile; at 80 ℃;
DOI:10.1016/j.tet.2018.02.046

Reference yield:

: 455-16-3
p-toluenesulfonyl fluoride

: 40078-73-7,131101-43-4
(4R,5R)/(4S,5S)-5-phenyl-4-tosyl-4,5-dihydrooxazole

Guidance literature:: Multi-step reaction with 2 steps

1: (i) nBuLi, THF, (ii) /BRN= 2208423/

2: NaCN / ethanol; tetrahydrofuran / 15 °C

With sodium cyanide; In tetrahydrofuran; ethanol;