1-Methyl-4-phenyl-1H-iMidazole

Base Information

• Chemical Name: 1-Methyl-4-phenyl-1H-iMidazole
• CAS No.: 2411-77-0
• Molecular Formula: C10H10N2
• Molecular Weight: 158.203
• Mol file: 2411-77-0.mol

Synonyms:1-methyl-4-phenylimidazole;1-Methyl-4-phenyl-1H-imidazole;4-phenyl-1-methylimidazole;1-methyl-4-phenylimidazol;

Chemical Property of 1-Methyl-4-phenyl-1H-iMidazole

Chemical Property:

• Boiling Point: 147 - 148 °C (0.1 mmHg)
• PSA: 17.82000
• LogP: 2.08710

Purity/Quality:

95% ^*data from raw suppliers

1-Methyl-4-phenyl-1H-imidazole 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Methyl-4-phenyl-1H-iMidazole

There total 30 articles about 1-Methyl-4-phenyl-1H-iMidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

4-Phenylimidazole (670-95-1) + methyl iodide (74-88-4) → N-methyl-4-phenylimidazole (2411-77-0)

Guidance literature:

4-Phenylimidazole; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 3h;

methyl iodide; In N,N-dimethyl-formamide; at 20 ℃; for 3h;

Reference yield: 81.0%

phenyllithium (591-51-5) + 4-iodo-1-methyl-1H-imidazole (71759-87-0) → N-methyl-4-phenylimidazole (2411-77-0)

Guidance literature:

phenyllithium; In tetrahydrofuran; at -78 - 20 ℃; for 3h;

4-iodo-1-methyl-1H-imidazole; With copper(l) iodide; N-cyclohexyl-1-[2-(diphenylphosphanyl)phenyl]methanimine; palladium dichloride; In tetrahydrofuran; at 20 ℃; for 18h;

DOI:10.1021/acs.joc.7b02004

Reference yield: 77.0%

4-bromo-1-methyl-1H-imidazole (25676-75-9) + 5,5-dimethyl-2-phenyl-1,3,2-dioxaborinane (5123-13-7) → N-methyl-4-phenylimidazole (2411-77-0)

Guidance literature:

With 4'-phenyl-2,2':6',2-terpyridine; potassium methanolate; cobalt(II) chloride; In N,N-dimethyl-formamide; at 80 ℃; for 16h; Sealed tube; Inert atmosphere; Glovebox;

DOI:10.1021/acs.organomet.7b00726

upstream raw materials:

1-methyl-4-phenyl-1,3-dihydro-imidazol-2-one

1-methyl-4-phenyl-1,3-dihydroimidazole-2-thione

diazomethane

methanol

Downstream raw materials:

1,3-dimethyl-4-phenyl-1H-imidazol-2-ium iodide

N'-benzoyl-N-methyl-N-formylurea

2-(1-methyl-4-phenyl-1H-imidazol-2-yl)ethanol

1-methyl-4-phenyl-1H-imidazole-2-carbaldehyde