Technology Process of 4-(7-(2-[18F]fluoroethoxy)quinoxalin-2-yl)-N,N-dimethylaniline
There total 10 articles about 4-(7-(2-[18F]fluoroethoxy)quinoxalin-2-yl)-N,N-dimethylaniline which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
potassium carbonate; [2.2.2]cryptande; [18F]fluoride ion, cyclotron produced, NCA;
In
acetonitrile;
at 100 ℃;
for 0.166667h;
DOI:10.1021/ml4000707
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: phosphonic acid diethyl ester; triethylamine / tetrahydrofuran / 11 h / 0 - 20 °C
2.1: dimethyl sulfoxide / 4 h / 20 °C
3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 0 - 50 °C
4.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 105 °C
4.2: 105 °C
5.1: pyridine / 0 - 20 °C
6.1: potassium carbonate; [2.2.2]cryptande; [18F]fluoride ion, cyclotron produced, NCA / acetonitrile / 0.17 h / 100 °C
With
pyridine; tetrabutyl ammonium fluoride; potassium carbonate; triethylamine; phosphonic acid diethyl ester; [2.2.2]cryptande; [18F]fluoride ion, cyclotron produced, NCA;
In
tetrahydrofuran; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/ml4000707
- Guidance literature:
-
Multi-step reaction with 2 steps
1: pyridine / 0 - 20 °C
2: potassium carbonate; [2.2.2]cryptande; [18F]fluoride ion, cyclotron produced, NCA / acetonitrile / 0.17 h / 100 °C
With
pyridine; potassium carbonate; [2.2.2]cryptande; [18F]fluoride ion, cyclotron produced, NCA;
In
acetonitrile;
DOI:10.1021/ml4000707
