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2,2-dibromo-1-(4-(dimethylamino)phenyl)ethan-1-one is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

210832-81-8

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210832-81-8 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 210832-81-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,1,0,8,3 and 2 respectively; the second part has 2 digits, 8 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 210832-81:
(8*2)+(7*1)+(6*0)+(5*8)+(4*3)+(3*2)+(2*8)+(1*1)=98
98 % 10 = 8
So 210832-81-8 is a valid CAS Registry Number.

210832-81-8Relevant articles and documents

Radiosynthesis of SPECT tracers: Via a copper mediated 123I iodination of (hetero)aryl boron reagents

Wilson, Thomas C.,McSweeney, Greg,Preshlock, Sean,Verhoog, Stefan,Tredwell, Matthew,Cailly, Thomas,Gouverneur, Véronique

supporting information, p. 13277 - 13280 (2016/11/17)

A general method for the copper mediated nucleophilic 123I-iodination of (hetero)aryl boronic esters and acids has been developed. The broad substrate scope of this radiosynthetic approach allows access to [123I]DPA-713, [123I]IMPY, [123I]MIBG and [123I]IPEB that are four commonly used SPECT radiotracers. Our results infer that aryl boronic reagents can now be employed as common precursors for both fluorine-18 and iodine-123 radiolabelling.

INHIBITORS OF HISTONE DEACETYLASE

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Paragraph 0271, (2016/04/26)

This invention provides compounds that are inhibitors of HDAC2. The compounds (e.g., compounds according to Formula (I), (II), (IIa), (III), (IV), (V), or (VI)) accordingly are useful for treating, alleviating, or preventing a condition in a subject such as a neurological disorder, memory or cognitive function disorder or impairment, extinction learning disorder, fungal disease or infection, inflammatory disease, hematological disease, or neoplastic disease, or for improving memory or treating, alleviating, or preventing memory loss or impairment.

RADIOACTIVE FLUORINE-LABELED QUINOXALINE COMPOUND

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Paragraph 0048-0049, (2014/04/03)

Provided is a compound effective as a diagnostic imaging probe targeting amyloid and an agent for Alzheimer's disease diagnosis including the compound.

Structure-activity relationships and in vivo evaluation of quinoxaline derivatives for PET imaging of β-amyloid plaques

Yoshimura, Masashi,Ono, Masahiro,Matsumura, Kenji,Watanabe, Hiroyuki,Kimura, Hiroyuki,Cui, Mengchao,Nakamoto, Yuji,Togashi, Kaori,Okamoto, Yoko,Ihara, Masafumi,Takahashi, Ryosuke,Saji, Hideo

supporting information, p. 596 - 600 (2013/07/26)

This letter describes the synthesis, structure-activity relationships, and in vivo evaluation of a new series of 2-phenylquinoxaline (PQ) derivatives for imaging β-amyloid (Aβ) plaques in Alzheimer's disease (AD). In experiments in vitro, the affinity of

COMPOSITIONS AND METHODS FOR THE TREATMENT AND ANALYSIS OF NEUROLOGICAL DISORDERS

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Sheet 9/10, (2013/06/27)

Provided herein are compositions and methods for the treatment and analysis of neurological disorders. In particular, provided herein are small molecules targeted to amyloid-β (Aβ ) or metal-Aβ species for the treatment, diagnosis, or study of neurological conditions such as Alzheimer's disease (AD) and other diseases and conditions.

2-Arylimidazo[2,1-b]benzothiazoles: A new family of amyloid binding agents with potential for PET and SPECT imaging of Alzheimer's brain

Alagille, David,Dacosta, Herve,Baldwin, Ronald M.,Tamagnan, Gilles D.

scheme or table, p. 2966 - 2968 (2011/06/24)

We designed and synthesized a small series of 2-aryl-imidazo[2,1-b] benzothiazole, representing a combination of motifs from the two most potent amyloid imaging agents, PIB and IMPY. The binding affinity of the new compounds ranged from 6 to 133 nM. Among the best compounds, 3b (Ki = 6 nM) can be labeled with 11CH3 for PET imaging whereas 3j (K i = 10.9 nM) can be labeled with 123I for SPECT imaging.

Small molecule modulators of copper-induced Aβ aggregation

Hindo, Sarmad S.,Mancino, Allana M.,Braymer, Joseph J.,Liu, Yihong,Vivekanandan, Subramanian,Ramamoorthy, Ayyalusamy,Lim, Mi Hee

supporting information; experimental part, p. 16663 - 16665 (2010/02/15)

(Chemical Equation Presented) Our design of bifunctional metal chelators as chemical probes and potential therapeutics for Alzheimer's disease (AD) is based on the incorporation of a metal binding moiety into structural frameworks of Aβ aggregate-imaging

Compounds and amyloid probes thereof for therapeutic and imaging uses

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Page/Page column 28; 39, (2008/06/13)

The present invention provides compounds and amyloid probes thereof that allow for an antemortem method of diagnosing AD and quantitating the extent or progression of amyloid deposits (plaques) by in vivo imaging of amyloid and/or amyloid deposits in the

Intramolecular sensitisation of lanthanide(III) luminescence by acetophenone-containing ligands: The critical effect of para-substituents and solvent

Beeby, Andrew,Bushby, Lisa M.,Maffeo, Davide,Gareth Williams

, p. 48 - 54 (2007/10/03)

Tetraazamacrocyclic ligands have been prepared in which three of the four nitrogen atoms are functionalised with carboxylate donors and the fourth is alkylated with apara-substituted acetophenone group {-CH2C(O)C6H4-X, whe

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