(2S)-2-({[4-hydroxy-7-(trifluoromethyl)-3-quinolyl]carbonyl}amino)-3-phenylpropanoic acid

Base Information

Chemical Name:(2S)-2-({[4-hydroxy-7-(trifluoromethyl)-3-quinolyl]carbonyl}amino)-3-phenylpropanoic acid
CAS No.:1370478-26-4
Molecular Formula:C₂₀H₁₅F₃N₂O₄
Molecular Weight:404.345
Hs Code.:

Synonyms:(2S)-2-({[4-hydroxy-7-(trifluoromethyl)-3-quinolyl]carbonyl}amino)-3-phenylpropanoic acid

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Chemical Property of (2S)-2-({[4-hydroxy-7-(trifluoromethyl)-3-quinolyl]carbonyl}amino)-3-phenylpropanoic acid

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Technology Process of (2S)-2-({[4-hydroxy-7-(trifluoromethyl)-3-quinolyl]carbonyl}amino)-3-phenylpropanoic acid

There total 3 articles about (2S)-2-({[4-hydroxy-7-(trifluoromethyl)-3-quinolyl]carbonyl}amino)-3-phenylpropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 63-91-2,25191-15-5,658-69-5,67675-33-6
L-phenylalanine

: 391-02-6
4-hydroxy-7-trifluoromethyl-quinoline-3-carboxylic acid ethyl ester

: 1370478-26-4
(2S)-2-({[4-hydroxy-7-(trifluoromethyl)-3-quinolyl]carbonyl}amino)-3-phenylpropanoic acid

Guidance literature:: With potassium carbonate; In dimethyl sulfoxide; for 8h; Reflux;
DOI:10.1007/s00044-012-0020-3

Reference yield:

: 370-35-4
diethyl 2-({[3-(trifluoromethyl)phenyl]amino}methylidene)propanedioate

: 1370478-26-4
(2S)-2-({[4-hydroxy-7-(trifluoromethyl)-3-quinolyl]carbonyl}amino)-3-phenylpropanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: diphenylether / 1 h / 260 °C

2: potassium carbonate / dimethyl sulfoxide / 8 h / Reflux

With potassium carbonate; In diphenylether; dimethyl sulfoxide;
DOI:10.1007/s00044-012-0020-3

Reference yield:

: 98-16-8
3-trifluoromethylaniline

: 1370478-26-4
(2S)-2-({[4-hydroxy-7-(trifluoromethyl)-3-quinolyl]carbonyl}amino)-3-phenylpropanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: neat (no solvent) / 2 h / 120 - 130 °C

2: diphenylether / 1 h / 260 °C

3: potassium carbonate / dimethyl sulfoxide / 8 h / Reflux

With potassium carbonate; In diphenylether; dimethyl sulfoxide;
DOI:10.1007/s00044-012-0020-3