[(1S,2R)-2-(3-Methoxy-phenyl)-cyclopropyl]-dipropyl-amine

Base Information

• Chemical Name: [(1S,2R)-2-(3-Methoxy-phenyl)-cyclopropyl]-dipropyl-amine
• CAS No.: 110901-93-4
• Molecular Formula: C₁₆H₂₅NO
• Molecular Weight: 247.381
• Mol file: 110901-93-4.mol

Synonyms:[(1S,2R)-2-(3-Methoxy-phenyl)-cyclopropyl]-dipropyl-amine

Chemical Property of [(1S,2R)-2-(3-Methoxy-phenyl)-cyclopropyl]-dipropyl-amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [(1S,2R)-2-(3-Methoxy-phenyl)-cyclopropyl]-dipropyl-amine

There total 10 articles about [(1S,2R)-2-(3-Methoxy-phenyl)-cyclopropyl]-dipropyl-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

1-iodo-propane (107-08-4) + (1S,2R)-2-(3-Methoxy-phenyl)-cyclopropylamine (110901-91-2,732211-88-0) → [(1S,2R)-2-(3-Methoxy-phenyl)-cyclopropyl]-dipropyl-amine (110901-93-4)

Guidance literature:

With potassium carbonate; In acetonitrile; for 96h; Ambient temperature;

DOI:10.1021/jm00396a014

Reference yield:

trans-3-methoxycinnamic acid (6099-04-3,17570-26-2) → [(1S,2R)-2-(3-Methoxy-phenyl)-cyclopropyl]-dipropyl-amine (110901-93-4)

Guidance literature:

Multi-step reaction with 9 steps

2: Pd(OAc)2 / diethyl ether; CH₂Cl₂ / 1 h / -10 - -5 °C

3: NaOH / methanol / 4 h / Ambient temperature

4: SOCl₂ / 0.75 h / 55 °C

5: 35 percent / Et₃N / CH₂Cl₂ / 1.) 0 deh C, 30 min, 2.) room temperature, overnight

6: 94 percent / H₂SO₄ / dioxane / 24 h / 100 °C

7: diphenylphosphoryl azide, Et₃N / 27 h / 90 °C

8: 1N HCl / 5 h / 100 °C

9: 82 percent / K₂CO₃ / acetonitrile / 96 h / Ambient temperature

With hydrogenchloride; sodium hydroxide; thionyl chloride; sulfuric acid; diphenylphosphoranyl azide; potassium carbonate; triethylamine; palladium diacetate; In 1,4-dioxane; methanol; diethyl ether; dichloromethane; acetonitrile;

DOI:10.1021/jm00396a014

Reference yield:

trans-3-(3-methoxyphenyl)acrylic acid methyl ester (38693-90-2) → [(1S,2R)-2-(3-Methoxy-phenyl)-cyclopropyl]-dipropyl-amine (110901-93-4)

Guidance literature:

Multi-step reaction with 8 steps

1: Pd(OAc)2 / diethyl ether; CH₂Cl₂ / 1 h / -10 - -5 °C

2: NaOH / methanol / 4 h / Ambient temperature

3: SOCl₂ / 0.75 h / 55 °C

4: 35 percent / Et₃N / CH₂Cl₂ / 1.) 0 deh C, 30 min, 2.) room temperature, overnight

5: 94 percent / H₂SO₄ / dioxane / 24 h / 100 °C

6: diphenylphosphoryl azide, Et₃N / 27 h / 90 °C

7: 1N HCl / 5 h / 100 °C

8: 82 percent / K₂CO₃ / acetonitrile / 96 h / Ambient temperature

With hydrogenchloride; sodium hydroxide; thionyl chloride; sulfuric acid; diphenylphosphoranyl azide; potassium carbonate; triethylamine; palladium diacetate; In 1,4-dioxane; methanol; diethyl ether; dichloromethane; acetonitrile;

DOI:10.1021/jm00396a014

upstream raw materials:

1-iodo-propane

(1S,2R)-2-(3-Methoxy-phenyl)-cyclopropylamine

trans-3-methoxycinnamic acid

trans-3-(3-methoxyphenyl)acrylic acid methyl ester