N-(2-formyl-4-hydroxypyrimidin-5-yl)-2,2-diphenylacetamide

Base Information

• Chemical Name: N-(2-formyl-4-hydroxypyrimidin-5-yl)-2,2-diphenylacetamide
• CAS No.: 1428548-69-9
• Molecular Formula: C₁₉H₁₅N₃O₃
• Molecular Weight: 333.346
• Mol file: 1428548-69-9.mol

Synonyms:N-(2-formyl-4-hydroxypyrimidin-5-yl)-2,2-diphenylacetamide

Chemical Property of N-(2-formyl-4-hydroxypyrimidin-5-yl)-2,2-diphenylacetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(2-formyl-4-hydroxypyrimidin-5-yl)-2,2-diphenylacetamide

There total 3 articles about N-(2-formyl-4-hydroxypyrimidin-5-yl)-2,2-diphenylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-((benzyloxy)methyl)-5-nitropyrimidin-4-ol (1428548-65-5) → N-(2-formyl-4-hydroxypyrimidin-5-yl)-2,2-diphenylacetamide (1428548-69-9)

Guidance literature:

Multi-step reaction with 4 steps

1: sodium dithionite; water / tetrahydrofuran / 4 h / 20 °C

2: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C

3: palladium on activated charcoal; ammonium formate / methanol / 5 h / Reflux

4: Dess-Martin periodane / dichloromethane / 0.33 h / 20 °C

With sodium dithionite; palladium on activated charcoal; water; ammonium formate; Dess-Martin periodane; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

N-(2-((benzyloxy)methyl)-4-hydroxypyrimidin-5-yl)-2,2-diphenylacetamide (1428548-67-7) → N-(2-formyl-4-hydroxypyrimidin-5-yl)-2,2-diphenylacetamide (1428548-69-9)

Guidance literature:

Multi-step reaction with 2 steps

1: palladium on activated charcoal; ammonium formate / methanol / 5 h / Reflux

2: Dess-Martin periodane / dichloromethane / 0.33 h / 20 °C

With palladium on activated charcoal; ammonium formate; Dess-Martin periodane; In methanol; dichloromethane;

Reference yield:

5-amino-2-((benzyloxy)methyl)pyrimidin-4-ol (1428548-66-6) → N-(2-formyl-4-hydroxypyrimidin-5-yl)-2,2-diphenylacetamide (1428548-69-9)

Guidance literature:

Multi-step reaction with 3 steps

1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C

2: palladium on activated charcoal; ammonium formate / methanol / 5 h / Reflux

3: Dess-Martin periodane / dichloromethane / 0.33 h / 20 °C

With palladium on activated charcoal; ammonium formate; Dess-Martin periodane; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; N,N-dimethyl-formamide;

upstream raw materials:

2-((benzyloxy)methyl)-5-nitropyrimidin-4-ol

5-amino-2-((benzyloxy)methyl)pyrimidin-4-ol

N-(2-((benzyloxy)methyl)-4-hydroxypyrimidin-5-yl)-2,2-diphenylacetamide

Downstream raw materials:

5-(2,2-diphenylacetarnido)-4-hydroxypyrimidine-2-carboxylic acid

methyl 2-(5-(2,2-diphenylacetamido)-4-hydroxypyrimidine-2-carboxamido)acetate

2-(5-(2,2-diphenylacetamido)-4-hydroxypyrimidine-2-carboxamido)acetic acid

ethyl 3-(5-(2,2-diphenylacetamido)-4-hydroxypyrimidin-2-yl)isoxazole-5-carboxylate