Technology Process of ethyl 3-(5-(2,2-diphenylacetamido)-4-hydroxypyrimidin-2-yl)isoxazole-5-carboxylate
There total 6 articles about ethyl 3-(5-(2,2-diphenylacetamido)-4-hydroxypyrimidin-2-yl)isoxazole-5-carboxylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
N-(4-hydroxy-2-((hydroxyimino)methyl)pyrimidin-5-yl)-2,2-diphenylacetamide;
With
N-chloro-succinimide;
In
N,N-dimethyl-formamide;
at 20 - 60 ℃;
for 1h;
propynoic acid ethyl ester;
With
triethylamine;
In
N,N-dimethyl-formamide;
at 0 - 20 ℃;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: sodium dithionite; water / tetrahydrofuran / 4 h / 20 °C
2.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C
3.1: palladium on activated charcoal; ammonium formate / methanol / 5 h / Reflux
4.1: Dess-Martin periodane / dichloromethane / 0.33 h / 20 °C
5.1: hydroxylamine hydrochloride; sodium acetate / water / 2 h / 100 °C
6.1: N-chloro-succinimide / N,N-dimethyl-formamide / 1 h / 20 - 60 °C
6.2: 0 - 20 °C
With
N-chloro-succinimide; sodium dithionite; palladium on activated charcoal; hydroxylamine hydrochloride; water; ammonium formate; sodium acetate; Dess-Martin periodane; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C
2.1: palladium on activated charcoal; ammonium formate / methanol / 5 h / Reflux
3.1: Dess-Martin periodane / dichloromethane / 0.33 h / 20 °C
4.1: hydroxylamine hydrochloride; sodium acetate / water / 2 h / 100 °C
5.1: N-chloro-succinimide / N,N-dimethyl-formamide / 1 h / 20 - 60 °C
5.2: 0 - 20 °C
With
N-chloro-succinimide; palladium on activated charcoal; hydroxylamine hydrochloride; ammonium formate; sodium acetate; Dess-Martin periodane; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine;
In
methanol; dichloromethane; water; N,N-dimethyl-formamide;
