tert-butyl (+/-)-(2S,4S,5R)-2-methoxycarbonyl-5-phenylpyrrolidine-4-carboxylate

Base Information

Chemical Name:tert-butyl (+/-)-(2S,4S,5R)-2-methoxycarbonyl-5-phenylpyrrolidine-4-carboxylate
CAS No.:113273-65-7
Molecular Formula:C₁₇H₂₃NO₄
Molecular Weight:305.374
Hs Code.:

Synonyms:tert-butyl (+/-)-(2S,4S,5R)-2-methoxycarbonyl-5-phenylpyrrolidine-4-carboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of tert-butyl (+/-)-(2S,4S,5R)-2-methoxycarbonyl-5-phenylpyrrolidine-4-carboxylate

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Technology Process of tert-butyl (+/-)-(2S,4S,5R)-2-methoxycarbonyl-5-phenylpyrrolidine-4-carboxylate

There total 7 articles about tert-butyl (+/-)-(2S,4S,5R)-2-methoxycarbonyl-5-phenylpyrrolidine-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 1663-39-4,25232-27-3
tert-Butyl acrylate

: 66646-88-6
methyl 2-(benzylideneamino)acetate

: 113273-65-7
tert-butyl (+/-)-(2S,4S,5R)-2-methoxycarbonyl-5-phenylpyrrolidine-4-carboxylate

Guidance literature:: With triethylamine; lithium bromide; In tetrahydrofuran; for 24h; Ambient temperature;
DOI:10.1021/jo00242a008

Reference yield:

: 1663-39-4,25232-27-3
tert-Butyl acrylate

: 66646-88-6,120238-40-6,138495-05-3
(E)-N-benzylideneglycine methyl ester

: 113273-65-7
tert-butyl (+/-)-(2S,4S,5R)-2-methoxycarbonyl-5-phenylpyrrolidine-4-carboxylate

Guidance literature:: With silver fluoride; triethylamine; In dichloromethane; at 20 ℃;
DOI:10.1021/ol0514653

Reference yield:

: 100-52-7
benzaldehyde

: 113273-65-7
tert-butyl (+/-)-(2S,4S,5R)-2-methoxycarbonyl-5-phenylpyrrolidine-4-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: MgSO₄; Et₃N / CH₂Cl₂ / 1 h / 20 °C

1.2: CH₂Cl₂ / 20 °C

2.1: AgF; Et₃N / CH₂Cl₂ / 20 °C

With silver fluoride; magnesium sulfate; triethylamine; In dichloromethane;
DOI:10.1021/ol0514653